{"title":"精神药物对实验性小鼠癫痫发作的影响*","authors":"Gregory B. Fink , Ewart A. Swinyard","doi":"10.1002/jps.3030490807","DOIUrl":null,"url":null,"abstract":"<div><p>Of seven psychopharmacologic drugs screened by five assay procedures, only meprobamate ana phenaglycodol exhibited significant anticonvulsant activity. Chlorpromazine, promazine, reserpine, and hydroxyzine lowered the threshold for minimal seizures variously induced, whereas triflupromazine had no effect on seizure threshold. The data obtained correlate well with available clinical data and indicate the value of threshold seizure studies in animals for detecting agents which may cause convulsions in man.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 8","pages":"Pages 510-513"},"PeriodicalIF":0.0000,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490807","citationCount":"11","resultStr":"{\"title\":\"Effects of Psychopharmacologic Agents on Experimentally-Induced Seizures in Mice*\",\"authors\":\"Gregory B. Fink , Ewart A. Swinyard\",\"doi\":\"10.1002/jps.3030490807\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Of seven psychopharmacologic drugs screened by five assay procedures, only meprobamate ana phenaglycodol exhibited significant anticonvulsant activity. Chlorpromazine, promazine, reserpine, and hydroxyzine lowered the threshold for minimal seizures variously induced, whereas triflupromazine had no effect on seizure threshold. The data obtained correlate well with available clinical data and indicate the value of threshold seizure studies in animals for detecting agents which may cause convulsions in man.</p></div>\",\"PeriodicalId\":100839,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"volume\":\"49 8\",\"pages\":\"Pages 510-513\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jps.3030490807\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S009595531536279X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S009595531536279X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of Psychopharmacologic Agents on Experimentally-Induced Seizures in Mice*
Of seven psychopharmacologic drugs screened by five assay procedures, only meprobamate ana phenaglycodol exhibited significant anticonvulsant activity. Chlorpromazine, promazine, reserpine, and hydroxyzine lowered the threshold for minimal seizures variously induced, whereas triflupromazine had no effect on seizure threshold. The data obtained correlate well with available clinical data and indicate the value of threshold seizure studies in animals for detecting agents which may cause convulsions in man.
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