中华Tinospora sinensis蛋白酪氨酸磷酸酶1B抑制剂

Chronicles of Young Scientists Pub Date : 2012-07-01 DOI:10.4103/2229-5186.99569

Prasoon Gupta, Upasana Sharma, P. Gupta, R. Maurya

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引用次数: 5

摘要

生物测定定向分离鉴定了一个新的化合物，4-羟基十七烷基-6-烯酸乙酯(1)和三个已知的化合物(2-4)从Tinospora sinensis。通过光谱数据分析确定了1的结构。对分离得到的化合物进行了蛋白酪氨酸磷酸酶1B (PTP1B)抑制活性评价。化合物1和2的ic50分别为61.1 μM和74.2 μM，具有显著的抑制活性

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A novel protein tyrosine phosphatase 1B inhibitor from Tinospora sinensis

Bioassay-directed fractionation led to the identification of a new compound, 4-hydroxy-heptadec-6-enoic acid ethyl ester (1) together with three known compounds (2-4) from Tinospora sinensis. The structure of 1 was determined by analysis of spectroscopic data. The isolated compounds were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compounds 1 and 2 displayed significant inhibitory activity with IC 50 values 61.1 and 74.2 μM, respectively

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Chronicles of Young Scientists

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