Hongjuan Wang, Wei Hu, O. Saliy
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摘要

目的。研究介孔二氧化硅的孔径和形貌对酒石酸美托洛尔释放的影响。研究了含12.7 wt. %酒石酸美托洛尔的中空介孔二氧化硅氨基官能团样品作为活性物质控释的潜在载体。酒石酸美托洛尔的释放特性研究在以下条件下进行:溶出介质为pH为7.4的缓冲液(磷酸盐缓冲液);取样时间:0.5 h ~ 18 h。采用紫外可见分光光度计(Persee TU-190,北京,中国),光程长度为1 cm,最大波长为274 nm的石英比色管,测定液相中美托洛尔的浓度。在这项工作中,我们研究了介孔二氧化硅作为控制释放酒石酸美托洛尔的可能载体,美托洛尔是一种用于治疗心血管系统疾病的药物。所研究的材料为中空介孔二氧化硅样品,其氨基官能团尺寸为200 - 400nm,壳厚为20 - 30nm。通过测定美托洛尔浓度在10 ~ 300ppm范围内的吸收依赖关系,建立了美托洛尔量的标定曲线。根据药物释放试验公式计算得到的药物浓度相同,说明美托洛尔的释放是可控的。研究了齐鲁工业大学化学与化工学院以CO2气泡为模板,采用新工艺合成含氨基介孔二氧化硅空心球,并以酒石酸美托洛尔填充介孔二氧化硅空心球的控释性能。实用价值。美托洛尔的释放量在1小时内可达到50%,5小时内可达到90%,表明合成的介孔空心球可实现药物的可控释放,显示了具有刺激反应和靶向治疗载体的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ВПЛИВ РОЗМІРУ ПОР ТА МОРФОЛОГІЇ МЕЗОПОРИСТОГО КРЕМНІЮ НА ВИВІЛЬНЕННЯ МЕТОПРОЛОЛУ ТАРТРАТУ
Purpose. Study pore size effect and morphology of mesoporous silica on metoprolol tartrate release.Methodology. A sample of hollow mesoporous silicon dioxide with amino-functional groups containing 12.7 wt. % metoprolol tartrate has been investigated as potential carriers for the controlled release of active substance. Studies of the release profiles of metoprolol tartrate were performed under the following conditions: dissolution medium was buffer solution with a pH of 7.4 (phosphate buffer); sampling time: from 0.5 h before 18 h. The metoprolol concentration in the liquid phase was evaluated by a UV-Vis spectrophotometer (Persee TU-190, Beijing, China) by use of quartz cuvettes with an optical path length of 1 cm at a maximum wavelength of 274 nm.Findings. In this work we have studied mesoporous silica as possible carrier to controlled release of metoprolol tartrate, a drug used in the treatment of some diseases of the cardiovascular system. The material for research was a sample of hollow mesoporous silicon dioxide with amino-functional groups 200–400 nm in size and 20–30 nm in shell thickness. A calibrated curve to determine the amount of metoprolol was constructed by determining the absorption dependence of the concentration of metoprolol in the range from 10 to 300 ppm. The same drug concentration was obtained as calculated from the drug release test formula, which concludes that the release of metoprolol is controlled.Originality. The controlled release of a sample of hollow spheres of mesoporous silicon dioxide filled with metoprolol tartrate was studied, which was synthesized by the School of Chemistry and Chemical Engineering, Qilu University of Technology, using a new technology, where hollow spheres of mesoporous silicon dioxide with amino groups were synthesized using CO2 gas bubbles as templates.Practical value. The metoprolol release amount could achieve a 50% release amounts within 1 hour and 90% within 5 hours, indicating that the synthesized mesoporous hollow sphere could achieve controlled drug release, and shows the potential of carriers with stimulus response and targeted therapy.
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