Recurrence of SARS-CoV-2 RNA among Positive Covid-19 Cases

Coronavirus disease 2019 (Covid-19) is a highly infectious disease, and its replication decreasing rapidly after the first week, while some level of immunity is built up. A small proportion of discharged patients may become positive again for severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) RNA, even if they meet the discharge criteria. Re-infection of SARS-CoV-2 is an apparently uncommon entity and only a few case reports or case series have been reported from across the whole world. Herein, we have reported two rare Covid-19 cases with recurrence of positive SARS-CoV-2 RNA after a complete clinical cure. The first case was redetected with Covid-19 with more severity after a gap of approximately three weeks after cure, and the second case has recurred after approximately seven weeks with a complication of pulmonary thromboembolism. We report here, the first few cases of a more vigorous Covid-19 recurrence with SARS-CoV-2 RNA in India. J Microbiol Infect Dis 2021; 11(2):108-114.