{"title":"PERK对造血祖细胞进行重编程，以指导脾脏中促进肿瘤的骨髓生成","authors":"Mingyu Liu, Chong Wu, Shufeng Luo, Qiaomin Hua, Hai-Tian Chen, Yulan Weng, Junyu Xu, Huiling Lin, Lu Wang, Jinheng Li, Lan Zhu, Zhenhong Guo, Shi‐Mei Zhuang, Tiebang Kang, Limin Zheng","doi":"10.1084/jem.20211498","DOIUrl":null,"url":null,"abstract":"Liu et al. demonstrate that the PERK-triggered HSPC preconditioning in the spleen is essential for their myeloid descendant cells to become immune suppressors in response to subsequent tumor microenvironmental stimulation. A spleen-targeted PERK blockade could be an effective strategy of immunotherapy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen\",\"authors\":\"Mingyu Liu, Chong Wu, Shufeng Luo, Qiaomin Hua, Hai-Tian Chen, Yulan Weng, Junyu Xu, Huiling Lin, Lu Wang, Jinheng Li, Lan Zhu, Zhenhong Guo, Shi‐Mei Zhuang, Tiebang Kang, Limin Zheng\",\"doi\":\"10.1084/jem.20211498\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Liu et al. demonstrate that the PERK-triggered HSPC preconditioning in the spleen is essential for their myeloid descendant cells to become immune suppressors in response to subsequent tumor microenvironmental stimulation. A spleen-targeted PERK blockade could be an effective strategy of immunotherapy.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20211498\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20211498","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen
Liu et al. demonstrate that the PERK-triggered HSPC preconditioning in the spleen is essential for their myeloid descendant cells to become immune suppressors in response to subsequent tumor microenvironmental stimulation. A spleen-targeted PERK blockade could be an effective strategy of immunotherapy.
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