João Vicente Linhares Rodrigues , Luiz C. Bertges , Carolina F.M.G. Pimentel , Priscilla O. Neves , Renata L. Bormann , José Ricci Júnior , Pedro R. Nardelli , Gabriela C. Toledo
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引用次数: 1
摘要
在Juiz de Fora联邦大学(UFJF)生理学实验室进行的一项研究中，将40只wistar大鼠分为两组，一组给予生理盐水，另一组灌胃给予tegaserod, 1.0 ml/只，持续15天。34只动物，每组17只，完成了实验。替加塞罗德剂量为0.09 mg/kg。本研究旨在探讨加藤皂苷对wistar大鼠胃肠运输速度的影响。经解剖的消化道(从下食道到直肠)的显像读数用于评估肠道运输。放射示踪剂在所有动物解剖消化道中覆盖的距离的显影评估没有显示任何统计学意义上的差异(p = 0.1)。我们得出结论，0.09 mg/kg剂量的天冬苷对Wistar大鼠肠道运输没有加速作用。
TRÂNSITO GASTROINTESTINAL DE Rattus norvegicus (Berkenhout, 1769) (Rodentia:Muridae) APÓS ADMINISTRAÇÃO DE TEGASERODE
In a study conducted at the physiology laboratory of the Federal University of Juiz de Fora (UFJF), forty wistar rats were divided into two groups, one receiving saline, and the other gavage‐administered tegaserod, 1.0 ml/animal, for 15 days. Thirty‐four animals, seventeen in each group, reached the end of the experiment. Tegaserod dose was 0.09 mg/kg. The study aimed to assess the effects of tegaserod on the speed of gastrointestinal transit of wistar rats. Scintigraphic reading of the dissected digestive tracts (from the lower esophagus to the rectum) being used to assess intestinal transit. The scintigraphic assessment of the distance covered by the radiotracer in the dissected digestive tract of all animals did not show any statistically significant difference (p = 0.1). We conclude that tegaserod, in the 0.09 mg/kg dose, did not accelerate the intestinal transit of Wistar rats.
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