在印度克什米尔三级保健研究所从脓液样本中分离出的细菌病原体出现多药耐药和广泛耐药

Benazir Shazia, Asifa Bhat, B. Fomda, Shaista Nazir, Dekyong Angmo, S. Akhtar, Lenah Bashir
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摘要

背景:抗生素耐药性正在以难以控制的速度增长。最明显的原因是抗生素使用不当。耐多药(MDR)和广泛耐药(XDR)微生物是医院获得性感染的重要原因,给治疗带来挑战。没有关于这类生物的数据。因此,本研究旨在从脓液样本中鉴定各种微生物及其抗生素敏感性模式,从而为我院MDR和XDR微生物提供数据,指导合理使用抗生素,防止此类微生物的出现。方法:对501例抽脓患者进行了为期6个月的鉴定和抗生素敏感性研究。结果:培养阳性200株(40%),以需氧革兰氏阳性球菌为主,共分离110株(52.6%)。需氧革兰氏阴性杆菌99株(47.4%)。最常见的分离物为金黄色葡萄球菌[79(37.8%)]。革兰氏阳性菌对氨苄西林、阿莫西林-克拉维酸酯和喹诺酮类药物有较高的耐药性。革兰氏阴性菌对喹诺酮类耐药较多(55 ~ 84%),对碳青霉烯类和多粘菌素b高度敏感(111株(53.1%)为多耐药,19株(9.1%)为多耐药。结论:不同地区病原菌耐药谱存在差异。因此,必须了解当地的耐药模式,以便适当使用抗微生物药物。在我们的研究中,发现了相当比例的耐多药和一些XDR微生物。应采取紧急措施,尽量减少因不当使用抗生素而产生的耐药性,并应在开始治疗前确定致病病原体。关键词spus,分离株,抗生素,多重耐药,广泛耐药
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EMERGING MULTIDRUG RESISTANCE AND EXTENSIVE DRUG RESISTANCE IN BACTERIAL PATHOGENS ISOLATED FROM PUS SAMPLES AT A TERTIARY CARE INSTITUTE OF KASHMIR, INDIA
Background: The resistance to antibiotics is increasing at a pace faster than can be controlled. The most apparent reason is the in appropriate use of antibiotics. Multidrug resistant (MDR) and extensively drug resistant (XDR) organisms are an important cause of hospital-acquired infections, creating a therapeutic challenge. Data regarding such organisms is not available. Therefore, the study was done to identify various organisms and their antimicrobial sensitivity patterns from pus samples, thus providing data about MDR and XDR organisms in our institute and guiding the appropriate use of antibiotics to prevent the emergence of such organisms. Methodology: 501 pus aspirates were studied over a period of 6 months for identification and antibiotic sensitivity. Results: 200 (40%) samples were culture positive and aerobic Gram-positive cocci showed predominance with a total of 110 (52.6%) isolates. 99 (47.4%) isolates were aerobic Gram-negative bacilli. The most common isolate was Staphylococcus aureus [79 (37.8%)]. Gram-positive organisms showed higher resistance towards ampicillin, amoxicillin-clavulanate, and quinolones. Gram negatives organisms showed more resistance towards quinolones (55 to 84%) but were highly sensitive to carbapenems and polymyxin B. 111 (53.1%) isolates were MDR and 19 (9.1%) isolates were XDR. Conclusion: The resistance spectrum of pathogens varies in different regions. Therefore, local resistance patterns have to be known for appropriate antimicrobial use. In our study, a significant proportion of MDR along with some XDR organisms was seen. Urgent steps should be taken to minimize any resistance resulting due to inappropriate use of antibiotics, and identification of the causative pathogen before beginning therapy should be done. Keywordspus, isolates, antibiotics, multidrug resistant, extensively drug resistant.
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