{"title":"中药降糖药对糖尿病大鼠氧化应激及抗氧化状态的影响","authors":"S. Vasi, A. Austin","doi":"10.2174/1876524600902010048","DOIUrl":null,"url":null,"abstract":"Antioxidative potential of four commonly used Indian medicinal plants Gymnema sylvestre, Salacia reticulata, Cassia auriculata and Eugenia jambolanum was screened for its antidiabetic activity by streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. The results confirm that the herbs were not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential.","PeriodicalId":22762,"journal":{"name":"The Open Diabetes Journal","volume":"2015 1","pages":"48-52"},"PeriodicalIF":0.0000,"publicationDate":"2009-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"15","resultStr":"{\"title\":\"Effect of Herbal Hypoglycemics on Oxidative Stress and Antioxidant Status in Diabetic Rats\",\"authors\":\"S. Vasi, A. Austin\",\"doi\":\"10.2174/1876524600902010048\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Antioxidative potential of four commonly used Indian medicinal plants Gymnema sylvestre, Salacia reticulata, Cassia auriculata and Eugenia jambolanum was screened for its antidiabetic activity by streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. The results confirm that the herbs were not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential.\",\"PeriodicalId\":22762,\"journal\":{\"name\":\"The Open Diabetes Journal\",\"volume\":\"2015 1\",\"pages\":\"48-52\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Diabetes Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1876524600902010048\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Diabetes Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876524600902010048","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Herbal Hypoglycemics on Oxidative Stress and Antioxidant Status in Diabetic Rats
Antioxidative potential of four commonly used Indian medicinal plants Gymnema sylvestre, Salacia reticulata, Cassia auriculata and Eugenia jambolanum was screened for its antidiabetic activity by streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. The results confirm that the herbs were not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential.
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