生姜是否对SARS-CoV-2的ommicron BA.2.75有效?

Q3 Biochemistry, Genetics and Molecular Biology

Turkish Computational and Theoretical Chemistry Pub Date : 2023-12-15 DOI:10.33435/tcandtc.1198612

H. Saraç, Ahmet Demi̇rbaş, Burak Tüzün

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引用次数: 0

摘要

本文对生姜植物进行了研究。采用气相色谱-质谱法对该植物中的化学物质进行了鉴定。比较了测定的化学分子对SARS-CoV-2基因组变异的活性。我们的重点是确定生姜植物是否能在硅片上抑制SARS-CoV-2的Omicron。通过理论计算，通过气相色谱-质谱分析，发现生姜植物中含有多种化学物质。逐个检测这些化学物质，并计算其对SARS-CoV-2病毒的活性值。结果，检测到具有高活性的分子。研究了高活性分子的ADME/T性质，以考察其药物性质。根据ADME/T结果，这五种分子适合作为药物分子用于人体代谢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Could Zingiber officinale plant be effective against Omicron BA.2.75 of SARS-CoV-2?

Zingiber officinale plant was examined in this study. The chemicals found in this plant were identified using the GC-MS method. The activities of the determined chemical molecules against the SARS-CoV-2 Omicron variant were compared. We focused to determine whether Zingiber officinale plant would be an inhibitor against Omicron of SARS-CoV-2 in silico. As a result of theoretical calculations, Zingiber officinale plant was found to contain many chemicals as a result of GC-MS analysis. These chemicals were detected one by one and their activity values were calculated for the SARS-CoV-2 virus. As a result, molecules with high activity were detected. ADME/T properties were investigated in order to examine the drug properties of molecules with high activity. According to ADME/T results, these five molecules examined are suitable for use in human metabolism as drug molecules.

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来源期刊

Turkish Computational and Theoretical Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

2.40

自引率

0.00%

发文量