在配有 Hyperscan 脉冲同步回旋加速器的 Mevion S250i 质子治疗设施中进行欧洲原子能机构第 9 工作组-第 11 工作组联合遥计数器相互比较。

IF 0.2 3区 历史学 0 MEDIEVAL & RENAISSANCE STUDIES
Gabriele Zorloni, Geert Bosmans, Thomas Brall, Marco Caresana, Marijke De Saint-Hubert, Carles Domingo, Christian Ferrante, Francesca Ferrulli, Renata Kopec, Johannes Leidner, Vladimir Mares, Racell Nabha, Pawel Olko, Miguel Ángel Caballero-Pacheco, Werner Ruehm, Marco Silari, Liliana Stolarczyk, Jan Swakon, Marco Tisi, Sebastian Trinkl, Olivier Van Hoey, Gloria Vilches-Freixas
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引用次数: 0

摘要

目的 质子疗法比传统放射疗法的剂量分布更均匀,因此越来越受欢迎。健康组织受到的二次剂量主要是二次中子。商用雷姆计数器是在线评估中子环境剂量当量(H*(10))的重要仪器。不过,一般来说,要正确选择任何测量仪,都需要事先了解设施的类型和辐射场。新型 Mevion S250i 超扫描同步环形加速器将加速器直接安装在龙门架上。它提供扫描的 227 MeV 质子束,以 750 Hz 频率、10 µs 脉宽的脉冲形式传输,之后通过移频调制器系统对能量进行降级。这种环境对商用远程计数器来说尤其具有挑战性;因此,我们测试了一些最常用的远程计数器的可靠性,以了解它们在 Mevion S250i 杂散中子场中的极限。方法 这项工作由欧洲辐射剂量测定小组(EURADOS)推动,描述了在荷兰马斯特罗质子治疗中心(该中心拥有新型 Mevion S250i Hyperscan 系统)进行的远程计数器相互比较。在这次相互比较中使用了多台远程计数器(LUPIN、LINUS、WENDI-II、LB6411、NM2B-458、NM2B-495Pb),其中包括使用水箱模型模拟病人治疗方案。实验结果与文献中的模型和数据进行了比较。主要结果 我们发现,只有 LUPIN 可以在 20% 的不确定性范围内正确评估 H*(10)。所有其他雷姆计数器都低估了参考 H*(10),低估系数从 2 到 10 以上不等,这取决于探测器模型和每个脉冲的中子剂量。在脉冲场中,每个脉冲的中子剂量是基本参数,而平均中子剂量率则是次要参数。在模型周围的不同位置,以及距离模型 186 厘米到 300 厘米的距离上,测量到的平均中子 H*(10)为 150-200 µSv/GyRBE,单位治疗剂量投射到靶上。意义 我们的结果与采用被动能量调制的类似梅维昂设施的结果部分一致。与采用主动能量调制的设施进行的比较证实,当采用被动能量调制时,中子 H*(10)可增加 10 倍以上。梅维昂杂散中子场的环境极具挑战性,需要使用对高能中子(高达几百兆电子伏)敏感的特定雷姆计数器,并专门设计用于承受脉冲中子场。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Joint EURADOS WG9-WG11 rem-counter intercomparison in a Mevion S250i proton therapy facility with Hyperscan pulsed synchrocyclotron.

Objective Proton therapy is gaining popularity because of the improved dose delivery over conventional radiation therapy. The secondary dose to healthy tissues is dominated by secondary neutrons. Commercial rem-counters are valuable instruments for the on-line assessment of neutron ambient dose equivalent (H*(10)). In general, however, a priori knowledge of the type of facility and of the radiation field is required for the proper choice of any survey meter. The novel Mevion S250i Hyperscan synchrocyclotron mounts the accelerator directly on the gantry. It provides a scanned 227 MeV proton beam, delivered in pulses with a pulse width of 10 µs at 750 Hz frequency, which is afterwards degraded in energy by a range shifter modulator system. This environment is particularly challenging for commercial rem-counters; therefore, we tested the reliability of some of the most widespread rem-counters to understand their limits in the Mevion S250i stray neutron field. Approach This work, promoted by the European Radiation Dosimetry Group (EURADOS), describes a rem-counter intercomparison at the Maastro Proton Therapy centre in the Netherlands, which houses the novel Mevion S250i Hyperscan system. Several rem-counters were employed in the intercomparison (LUPIN, LINUS, WENDI-II, LB6411, NM2B-458, NM2B-495Pb), which included simulation of a patient treatment protocol employing a water tank phantom. The outcomes of the experiment were compared with models and data from the literature. Main results We found that only the LUPIN allowed for a correct assessment of H*(10) within a 20% uncertainty. All other rem-counters underestimated the reference H*(10) by factors from 2 to more than 10, depending on the detector model and on the neutron dose per pulse. In pulsed fields, the neutron dose per pulse is a fundamental parameter, while the average neutron dose rate is a secondary quantity. An average 150-200 µSv/GyRBE neutron H*(10) at various positions around the phantom and at distances between 186 cm and 300 cm from it was measured per unit therapeutic dose delivered to the target. Significance Our results are partially in line with results obtained at similar Mevion facilities employing passive energy modulation. Comparisons with facilities employing active energy modulation confirmed that the neutron H*(10) can increase up to more than a factor of 10 when passive energy modulation is employed. The challenging environment of the Mevion stray neutron field requires the use of specific rem-counters sensitive to high-energy neutrons (up to a few hundred MeV) and specifically designed to withstand pulsed neutron fields.

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来源期刊
BYZANTINISCHE ZEITSCHRIFT
BYZANTINISCHE ZEITSCHRIFT MEDIEVAL & RENAISSANCE STUDIES-
CiteScore
0.40
自引率
33.30%
发文量
48
期刊介绍: Steeped in tradition, this organ of international Byzantine studies covers literature, history and art history, including the related and peripheral disciplines, equally in all sections (essays, reviews, bibliographies) and thus contributes significantly to the support and development of Byzantine Studies.
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