乙二醛丙烯酰胺改性Κ-Carrageenan高吸水性高分子在给药系统中的应用

A. Prasetyaningrum, A. F. A. Raemas, N. Rokhati, B. Jos
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引用次数: 0

摘要

水凝胶是可生物降解的高吸水性聚合物(SAP),可以从多糖、脂质和蛋白质中获得。多糖包括纤维素、淀粉及其衍生物、海藻提取物,如卡拉胶、海藻酸盐、果胶和壳聚糖。卡拉胶是用碱性溶液提取红海藻汁液的结果。本研究的主要目的是通过添加乙二醛和丙烯酰胺作为交联剂,同时提高κ-卡拉胶SAP膜的强度和性能。在k-卡拉胶基SAP水凝胶化合物中加入丙烯酰胺(b/v为1 ~ 7%)和乙二醛作为交联剂(v /v为0 ~ 1,0 %)。用膨胀度和拉伸强度分析了SAP膜的物理性能。利用傅里叶变换红外(FTIR)和扫描电子显微镜(SEM)分析了复合膜的结构和形态特性。此外,还考察了磷酸氢盐对Poly(乙烯基吡咯烷酮)-碘释放的影响。研究表明,丙烯酰胺和乙二醛的加入可以改善改性后的κ-卡拉胶膜的物理性能。SEM表征表明,乙二醛的加入导致SAP中组织纤维的形成。FTIR光谱表明,在3294.42 cm-1(羧酸)处,改性SAP膜中形成了交叉键。在碱性条件下处理会增加药物的释放能力。关键词:κ卡拉胶;水凝胶;丙烯酰胺;乙二醛;药物输送
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of Glyoxal Acrylamide Modified Κ-Carrageenan as A Superabsorbent Polymer in Drug Delivery System
The hydrogel is superabsorbent polymers (SAP) that are biodegradable and can be obtained from polysaccharides, lipids, and proteins. Polysaccharides include cellulose, starch and their derivatives, seaweed extracts such as carrageenan, alginate, pectin, and chitosan. Carrageenan is the result of the extraction of red seaweed sap with an alkaline solution. The main objective of this study was to simultaneously increase the strength and properties of κ-carrageenan SAP film with the addition of glyoxal and acrylamide as crosslinkers. The addition of acrylamide (variated from 1 to 7 % b/v) into the k-Carrageenan based SAP hydrogel compound and the presence of glyoxal as crosslink agent (variated from 0 to 1,0 % v/v). The physical properties of the SAP films were analyze using swelling degree and tensile strength. The structural and morphological properties of composite films were analyzed using Fourier Transform Infrared (FTIR) and Scanning Electron Microscopy (SEM). In addition, the effect of pHs on the releasing drug Poly(vinylpyrrolidone)-Iodine was investigated. This research shows that the addition of acrylamide and glyoxal can improve the physical properties of the modified κ-carrageenan film. Characterization using SEM shows that the addition of glyoxal causes the formation of tissue fibers in SAP. FTIR spectra indicated the formation of cross bonds in modified SAP film at 3294.42 cm-1 (carboxylic acid). The treatment under alkaline conditions will increase drug release ability.Keywords: κ-carrageenan; hydrogels; acrylamide; glyoxal; drug delivery
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