Update Aetiopathogenesis and Treatment of Psoriasis: A Literature Review

Background: Psoriasis is a very common skin condition that is caused by an immune system problem. T-cells, dendritic cells, macrophages and neutrophils all play a role in the proliferation of keratinocytes. Several genetic and environmental factors are involved in the development of this condition. Objectives: The purpose of this study is to review aetiopathogenic causes and therapeutic aspects of psoriasis. Therefore, the literature review aims to address the following: Explore psoriasis theories and factors that influence psoriasis. Review of effectiveness of different treatment methods in the management of mild, moderate and severe psoriasis. In addition, there is a need to identify and evaluate new or novel therapies in the treatment of moderate and severe forms of psoriasis. Methods: A narrative literature review provides an overview of the extensive literature on the etiology, pathogenesis and treatment of psoriasis. The data comes from well reads articles published over the last 30 years (1992-2022). Electronic databases were taken from Google Scholar, PubMed, Medscape and the University of South Wales. Results: Two hundred two articles, which varied between literature reviews, systematic reviews, review articles, randomized controlled studies, meta-analyses and comparative studies. 100 out of 202 of the articles in this thesis focused on discussing the etiology, pathogenesis, pathophysiology and psoriasis treatments. Conclusion: Psoriasis is a multifactorial chronic disease. Genetics, immune and environmental factors play a significant role in its development. Psoriasis is a treatable but incurable disease that is widespread and has a significant impact on quality of life. Advances in understanding the etiology and pathogenesis of psoriasis will undoubtedly lead to the discovery of new treatments and better patient outcomes and improve quality of life for patients.