不同氧合水平下大鼠一氧化碳缺氧的代谢和通气反应

Henry Gautier, Cristina Murariu
{"title":"不同氧合水平下大鼠一氧化碳缺氧的代谢和通气反应","authors":"Henry Gautier,&nbsp;Cristina Murariu","doi":"10.1016/S0034-5687(01)00315-2","DOIUrl":null,"url":null,"abstract":"<div><p>Adult, conscious rats have been exposed to CO-induced hypoxia for 30 min in normoxia, ambient hypoxia (FI<sub>O<sub>2</sub></sub>=14%), or hyperoxia (FI<sub>O<sub>2</sub></sub>=40%). From arterial blood gas analyses, FICO was adjusted in all experimental conditions to obtain final arterial oxygen saturations (Sa<sub>O<sub>2</sub></sub>) of ∼60%. Oxygen uptake (<span><math><mtext>V</mtext><mtext>̇</mtext><msub><mi></mi><mn><mtext>O</mtext><msub><mi></mi><mn>2</mn></msub></mn></msub></math></span>), ventilation (<span><math><mtext>V</mtext><mtext>̇</mtext></math></span>) and colonic temperature (Tc) were measured in experiments carried out at an ambient temperature of either 25 or 15<!--> <!-->°C. It was found that CO hypoxia induced marked reductions in the hemoglobin O<sub>2</sub> half saturation pressure (P<sub>50</sub>). Furthermore, isolated reductions in Sa<sub>O<sub>2</sub></sub> (with Pa<sub>O<sub>2</sub></sub> constant) induced decreases in <span><math><mtext>V</mtext><mtext>̇</mtext><msub><mi></mi><mn><mtext>O</mtext><msub><mi></mi><mn>2</mn></msub></mn></msub></math></span> and Tc and increases in ventilation which, as compared with normoxia, were enhanced in ambient hypoxia and reduced but still significant in hyperoxia. As suggested by previous studies, the interactions between Sa<sub>O<sub>2</sub></sub> and Pa<sub>O<sub>2</sub></sub> which operate on the control of metabolism and ventilation originate probably in the central nervous system.</p></div>","PeriodicalId":20976,"journal":{"name":"Respiration physiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00315-2","citationCount":"2","resultStr":"{\"title\":\"Metabolic and ventilatory responses to CO hypoxia at different levels of oxygenation in the rat\",\"authors\":\"Henry Gautier,&nbsp;Cristina Murariu\",\"doi\":\"10.1016/S0034-5687(01)00315-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Adult, conscious rats have been exposed to CO-induced hypoxia for 30 min in normoxia, ambient hypoxia (FI<sub>O<sub>2</sub></sub>=14%), or hyperoxia (FI<sub>O<sub>2</sub></sub>=40%). From arterial blood gas analyses, FICO was adjusted in all experimental conditions to obtain final arterial oxygen saturations (Sa<sub>O<sub>2</sub></sub>) of ∼60%. Oxygen uptake (<span><math><mtext>V</mtext><mtext>̇</mtext><msub><mi></mi><mn><mtext>O</mtext><msub><mi></mi><mn>2</mn></msub></mn></msub></math></span>), ventilation (<span><math><mtext>V</mtext><mtext>̇</mtext></math></span>) and colonic temperature (Tc) were measured in experiments carried out at an ambient temperature of either 25 or 15<!--> <!-->°C. It was found that CO hypoxia induced marked reductions in the hemoglobin O<sub>2</sub> half saturation pressure (P<sub>50</sub>). Furthermore, isolated reductions in Sa<sub>O<sub>2</sub></sub> (with Pa<sub>O<sub>2</sub></sub> constant) induced decreases in <span><math><mtext>V</mtext><mtext>̇</mtext><msub><mi></mi><mn><mtext>O</mtext><msub><mi></mi><mn>2</mn></msub></mn></msub></math></span> and Tc and increases in ventilation which, as compared with normoxia, were enhanced in ambient hypoxia and reduced but still significant in hyperoxia. As suggested by previous studies, the interactions between Sa<sub>O<sub>2</sub></sub> and Pa<sub>O<sub>2</sub></sub> which operate on the control of metabolism and ventilation originate probably in the central nervous system.</p></div>\",\"PeriodicalId\":20976,\"journal\":{\"name\":\"Respiration physiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00315-2\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respiration physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0034568701003152\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiration physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0034568701003152","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

成年有意识大鼠在常氧、环境缺氧(FIO2=14%)或高氧(FIO2=40%)条件下暴露于co诱导的缺氧30分钟。根据动脉血气分析,在所有实验条件下调整FICO以获得最终动脉血氧饱和度(SaO2)为~ 60%。在25°C或15°C的环境温度下进行实验,测量吸氧(V O2)、通气量(V O2)和结肠温度(Tc)。结果发现,CO缺氧诱导血红蛋白O2半饱和压明显降低(P50)。此外,SaO2的单独降低(PaO2不变)导致V (O2)和Tc的降低以及通气量的增加,与常氧相比,在环境缺氧时增强,在高氧时减弱但仍然显著。根据以往的研究,SaO2和PaO2之间的相互作用可能起源于中枢神经系统,并对代谢和通气的控制起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic and ventilatory responses to CO hypoxia at different levels of oxygenation in the rat

Adult, conscious rats have been exposed to CO-induced hypoxia for 30 min in normoxia, ambient hypoxia (FIO2=14%), or hyperoxia (FIO2=40%). From arterial blood gas analyses, FICO was adjusted in all experimental conditions to obtain final arterial oxygen saturations (SaO2) of ∼60%. Oxygen uptake (V̇O2), ventilation (V̇) and colonic temperature (Tc) were measured in experiments carried out at an ambient temperature of either 25 or 15 °C. It was found that CO hypoxia induced marked reductions in the hemoglobin O2 half saturation pressure (P50). Furthermore, isolated reductions in SaO2 (with PaO2 constant) induced decreases in V̇O2 and Tc and increases in ventilation which, as compared with normoxia, were enhanced in ambient hypoxia and reduced but still significant in hyperoxia. As suggested by previous studies, the interactions between SaO2 and PaO2 which operate on the control of metabolism and ventilation originate probably in the central nervous system.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信