EVALUATION OF LIPID PROFILE AND THYROID HORMONE LEVELS IN PATIENTS WITH CHRONIC PANCREATITIS COMBINED WITH HYPOTHYROIDISM

With hypothyroidism (HТ) there is a change in homeostasis in tissues sensitive to thyroidhormones, which in its turn leads to a violation of fat metabolism. HT induces a significantincrease in lipid peroxidation and reduces the activity of antioxidant enzymes, oxidativestress, which is formed in HT, can play a key role in the progression of pancreaticdysfunction (PD).Purpose – to study the indicators of the lipid profile and the level of thyroid hormones inpatients with CP and CP, combined with HT.Material and methods 107 people were examined, including 29 patients with CP (group1), 30 patients with HT (group 2), 28 patients with CP on the associated with HT (group3), 20 almost healthy individuals (AHI) (group 4). The age of the examined patientsranged from 44 to 72 years, the main percentage (53%) was dominated by people ofworking age from 49 to 58 years (mean age - 54.26 ± 1.87). The gender distribution wascomparable across all groups. According to the local ethics committees for biomedicalresearch, guided by Ukrainian health legislation and the 2000 a. declaration of Helsinki,all patients and AHI surveyed gave written informed consent to participate in the study.All patients were hospitalized at the Chernivtsi Regional Clinical Hospital and theChernivtsi Regional Endocrinology Center.The results. According to the results of the study of the lipid profile in all groups of patientsthere were manifestations of dyslipidemia, but they were more pronounced in patientswith combined pathology: total cholesterol increased 36.04% (p <0.05) compared withAHI; 21.37% compared with the group of patients with CP and by 15.06% compared withthe group of patients with CP. The level of triglycerides increased in the group of patientswith CP, associated with HT in 2.2 times compared with AHI group, in comparison ofthe groups of the combined pathology with CP patients and with HT patients it is higher 34.51% and 9.4% (p <0, 05). Patients in all 3 groups had an increase in very low-densitylipoprotein cholesterol compared with AHI, with a tendency to increase in patients inwhom CP was combined with HT.Conclusion. The most pronounced signs of dyslipidemia were found in patients with CPcombined with HT, which confirms the close pathogenetic link between these nosologies- a marker of thyroid insufficiency (increased TSH levels, decreased T4), manifestationsof dyslipidemia, which is a predictor of pancreatic lesions. The study of comorbidity ofthese nosologies is a promising area of clinical gastroenterology and endocrinology. Theresults prove the need for more detailed and in-depth study of the clinical course andinteraction of these diseases, in order to optimize the therapeutic treatment regimens, thatwill allow to avoid the development of complications and disability.