{"title":"以BF3-Et2O为催化剂一锅多组分合成β-乙酰氨基酮","authors":"P. Rawat, P. Rawat, Piyush Kumar","doi":"10.5138/ijaps.v4i2.903","DOIUrl":null,"url":null,"abstract":"Starting from different ketones 1a-1f , aldehyde 2a-2g , and acetonitriles 3a-3d we synthesize some bioactive β- Acetamido carbonyl compounds 4a-4h . We also attempted to synthesize these compounds by using phenylacetone and deoxybenzoins in place of ketones to afford the products 4i-4j . 1 H-NMR spectra are presented. On the basis of QSAR studies, some compounds were tested for their anti-thrombotic activity in mice. Compound 4f , 4h and 4j were found to exhibit less percentage protection.","PeriodicalId":13912,"journal":{"name":"International Journal of Drug Delivery","volume":"7 1","pages":"326-328"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"One-Pot Multicomponent Synthesis of β-Acetamido Ketones Using BF3-Et2O as Catalyst\",\"authors\":\"P. Rawat, P. Rawat, Piyush Kumar\",\"doi\":\"10.5138/ijaps.v4i2.903\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Starting from different ketones 1a-1f , aldehyde 2a-2g , and acetonitriles 3a-3d we synthesize some bioactive β- Acetamido carbonyl compounds 4a-4h . We also attempted to synthesize these compounds by using phenylacetone and deoxybenzoins in place of ketones to afford the products 4i-4j . 1 H-NMR spectra are presented. On the basis of QSAR studies, some compounds were tested for their anti-thrombotic activity in mice. Compound 4f , 4h and 4j were found to exhibit less percentage protection.\",\"PeriodicalId\":13912,\"journal\":{\"name\":\"International Journal of Drug Delivery\",\"volume\":\"7 1\",\"pages\":\"326-328\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Drug Delivery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5138/ijaps.v4i2.903\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Drug Delivery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5138/ijaps.v4i2.903","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
One-Pot Multicomponent Synthesis of β-Acetamido Ketones Using BF3-Et2O as Catalyst
Starting from different ketones 1a-1f , aldehyde 2a-2g , and acetonitriles 3a-3d we synthesize some bioactive β- Acetamido carbonyl compounds 4a-4h . We also attempted to synthesize these compounds by using phenylacetone and deoxybenzoins in place of ketones to afford the products 4i-4j . 1 H-NMR spectra are presented. On the basis of QSAR studies, some compounds were tested for their anti-thrombotic activity in mice. Compound 4f , 4h and 4j were found to exhibit less percentage protection.
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