{"title":"2型糖尿病的遗传学:复杂性的后果","authors":"Mark McCarthy","doi":"10.1046/j.1466-9218.2000.00017.x","DOIUrl":null,"url":null,"abstract":"<p>Type 2 diabetes affects a significant proportion of the World’s population and shows strong familial association. A richer molecular understanding of the aetiological mechanisms is a prerequisite for the development of improved therapeutic and preventative options to ameliorate the burden of disease. The genome-scale analyses now possible should allow the major susceptibility genes for type 2 diabetes to be identified, provided due respect is paid to the inevitable complexities associated with the genetic analysis of multifactorial traits.</p>","PeriodicalId":100575,"journal":{"name":"GeneScreen","volume":"1 2","pages":"81-84"},"PeriodicalIF":0.0000,"publicationDate":"2008-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1466-9218.2000.00017.x","citationCount":"1","resultStr":"{\"title\":\"The genetics of type 2 diabetes: the consequences of complexity\",\"authors\":\"Mark McCarthy\",\"doi\":\"10.1046/j.1466-9218.2000.00017.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Type 2 diabetes affects a significant proportion of the World’s population and shows strong familial association. A richer molecular understanding of the aetiological mechanisms is a prerequisite for the development of improved therapeutic and preventative options to ameliorate the burden of disease. The genome-scale analyses now possible should allow the major susceptibility genes for type 2 diabetes to be identified, provided due respect is paid to the inevitable complexities associated with the genetic analysis of multifactorial traits.</p>\",\"PeriodicalId\":100575,\"journal\":{\"name\":\"GeneScreen\",\"volume\":\"1 2\",\"pages\":\"81-84\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1046/j.1466-9218.2000.00017.x\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"GeneScreen\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1046/j.1466-9218.2000.00017.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"GeneScreen","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1046/j.1466-9218.2000.00017.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The genetics of type 2 diabetes: the consequences of complexity
Type 2 diabetes affects a significant proportion of the World’s population and shows strong familial association. A richer molecular understanding of the aetiological mechanisms is a prerequisite for the development of improved therapeutic and preventative options to ameliorate the burden of disease. The genome-scale analyses now possible should allow the major susceptibility genes for type 2 diabetes to be identified, provided due respect is paid to the inevitable complexities associated with the genetic analysis of multifactorial traits.
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