Montserrat González-Cuevas , Odile Romero , Manuel Toledo , Manuel Quintana , Roser Cambrodí , Estevo Santamarina , Maria José Jurado , Alex Ferrer , Xavier Salas-Puig
{"title":"辅助安眠药对癫痫患者睡眠质量及白天嗜睡的影响","authors":"Montserrat González-Cuevas , Odile Romero , Manuel Toledo , Manuel Quintana , Roser Cambrodí , Estevo Santamarina , Maria José Jurado , Alex Ferrer , Xavier Salas-Puig","doi":"10.1016/j.ebcr.2016.10.002","DOIUrl":null,"url":null,"abstract":"<div><p>This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4<!--> <!-->mg/day for 3<!--> <!-->months) on the sleep-wake cycle and daytime somnolence in adult patients (n<!--> <!-->=<!--> <!-->10) with focal seizures. A ><!--> <!-->50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment. In conclusion, low-dose perampanel may improve seizure control without affecting the sleep characteristics or daytime somnolence in patients with epilepsy.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2016.10.002","citationCount":"17","resultStr":"{\"title\":\"Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy\",\"authors\":\"Montserrat González-Cuevas , Odile Romero , Manuel Toledo , Manuel Quintana , Roser Cambrodí , Estevo Santamarina , Maria José Jurado , Alex Ferrer , Xavier Salas-Puig\",\"doi\":\"10.1016/j.ebcr.2016.10.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4<!--> <!-->mg/day for 3<!--> <!-->months) on the sleep-wake cycle and daytime somnolence in adult patients (n<!--> <!-->=<!--> <!-->10) with focal seizures. A ><!--> <!-->50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment. In conclusion, low-dose perampanel may improve seizure control without affecting the sleep characteristics or daytime somnolence in patients with epilepsy.</p></div>\",\"PeriodicalId\":56365,\"journal\":{\"name\":\"Epilepsy and Behavior Case Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ebcr.2016.10.002\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epilepsy and Behavior Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213323216300652\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epilepsy and Behavior Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213323216300652","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy
This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment. In conclusion, low-dose perampanel may improve seizure control without affecting the sleep characteristics or daytime somnolence in patients with epilepsy.
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