瓦加杜古,布基纳法索癫痫持续状态的病因学谱:一项前瞻性横断面多中心医院研究

Djingri Labodi Lompo, Nagaonlé Éric Some, Pegde-bamba Carine Dakouré, Adja Mariam Ouédraogo, O. Diallo, C. Napon, J. Kaboré, A. Millogo
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引用次数: 0

摘要

在撒哈拉以南非洲,癫痫持续状态(SE)的脑血管病因与传染性脑病变一起呈上升趋势。我们研究的目的是描述在布基纳法索瓦加杜古的SE的病因谱,这是一个高风险的SE环境。患者和方法:这是一项前瞻性、横断面、描述性、多中心和医院研究,研究对象是2015年1月1日至2019年12月31日在布基纳法索瓦加杜古市大学医院连续住院的SE患者。采用Epi-info 7.2.1.0软件对患者的社会人口学、临床、临床旁(生物学、临界和/或临界间期脑电图、神经放射学)特征和病因学资料进行分析:计算数字、频率、平均值。显著性率设为0.05。结果:共收集SE住院患者91例,男性占73.62%;平均年龄36.6岁+/24.5岁(2天86岁);25例患者(27.5%)已经患有已知的癫痫。全身性强直-阵挛性SE和局灶性SE伴双侧惊厥是最常见的发作类型,分别为46例(50.5%)和27例(29.7%)。EME发作的平均持续时间为18小时+/31(5分钟6天)。入院时主要临床症状为集中运动障碍36例(46.7%),发热28例(30.8%);白细胞增多症23例(25.3%)和贫血22例(24.2%)是主要的实验室异常。脑CT以后遗症33例(51.6%)、急性脑卒中14例(21.9%)、急性脑膜脑炎8例(12.5%)最为常见。有急性脑疾病症状的se 61例(67%),以感染性病因为主30例(33%),急性脑卒中为主16例(17.6%)。病因的非急性或后遗症性se中,外伤性脑损伤后遗症10例(11%),脑卒中后遗症8例(8.8%)最多。结论:瓦加杜古神经病患者SE的病因以中枢神经系统感染、急性或后遗症脑卒中和颅脑外伤为主。防治传染病和预防血管危险因素将有助于减少急诊的频率和严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study
Introduction: In sub-Saharan Africa, cerebrovascular aetiologies of status epilepticus (SE) are on the rise alongside infectious brain lesions. The aim of our study was to describe the etiologic spectrum of SE in Ouagadougou, Burkina Faso, in a high risk SE setting. Patients and methods: This is a prospective, cross-sectional, descriptive, multicenter and hospital study of patients hospitalized consecutively in the university hospitals of the city of Ouagadougou, in Burkina Faso, from 01/01/2015 to 12/31/2019, for SE. The sociodemographic, clinical, paraclinical (biological, critical and / or intercritical EEG, neuroradiological) characteristics and the aetiological data of the patients were analyzed using the Epi-info 7.2.1.0 software: calculations of numbers, frequencies, averages. The significance rate was set at 0.05. Results: 91 patients hospitalized for SE were collected, with a male predominance (73.62%). The mean age was 36.6 years +/24.5 years (2 days and 86 years); 25 patients (27.5%) already had known epilepsy. Generalized tonic-clonic SE from the start and focal SE with convulsive bilateralization were the most common seizure types with 46 cases (50.5%) and 27 cases (29.7%), respectively. The average duration of an EME episode was 18 hours +/31 (5 minutes 6 days). On admission, a focused motor deficit with 36 cases (46.7%) and fever in 28 patients (30.8%) were the main clinical signs; hyperleukocytosis with 23 cases (25.3) and anemia with 22 cases (24.2%), were the main laboratory abnormalities. On cerebral CT scan, sequelae with 33 cases (51.6%), acute stroke with 14 cases (21.9%) and acute meningoencephalitis with 8 cases (12.5%), were the most frequent. SEs symptomatic of acute brain disease, with 61 cases (67%), were dominated by infectious etiologies with 30 cases (33%) and acute strokes with 16 cases (17.6%). Among the non-acute or sequelae SEs of etiology, the sequelae of traumatic brain injury with 10 cases (11%) and the sequelae of stroke with 8 cases (8.8%) were the most represented. Conclusion: The aetiologies of SE are dominated in the Ouagadougou CHUs by CNS infections, acute or sequelae strokes and cranio-encephalic trauma. The fight against infectious diseases and the prevention of vascular risk factors will help reduce the frequency and severity of EMEs.
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