编者聚焦/专题5:误解和接受基于证据的非手术干预膝关节骨关节炎。定性研究。

S. Leopold
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引用次数: 5

摘要

许多外科医生不喜欢或不信任像荟萃分析这样的密集研究方法,甚至有经验的读者——包括经验丰富的同行评议人——在需要大量计算能力才能将数据分解成答案时也会望而却步,就像使用机器学习的研究一样。所以,这个月让我们从所有的数学中休息一下,尽情享受本月重点报道节目中一些伟大的定性研究的光芒。看不到小数点或p值。我是否听到有人说,“什么是定性研究?”我并不感到惊讶。据我所知,在我加入团队的7年里,我们只在《临床骨科与相关研究》上发表了两篇论文[10,12],使用了定性或基于访谈的方法,我也看到这些方法在我们专业的其他领先的通用期刊上也有类似的零星应用[6,8]。那太糟糕了。临床医生(和临床研究的读者)最熟悉的定量方法——病例系列,历史对照研究,甚至随机试验——可以告诉我们是什么和什么时候,但它们缺乏为什么和如何。具体来说,它们很少或根本没有深入了解我们的病人为什么做出他们所做的决定,以及这些病人是如何看待(有时是误解)关于他们自己身体的重要事实的。原则上,他们的医生试图解释这些事实。由于这些原因,我很高兴在本月的CORR中分享一个来自澳大利亚墨尔本的乔-安妮·曼斯基-南克维斯博士的研究小组的精彩例子,它为患者对膝关节关节炎的常见误解提供了一些深刻的见解。包括第一作者Samantha Bunzli博士在内的作者对20多名正在等待手术的患者进行了深入的采访,以确定患者对骨关节炎是什么、是什么引起的、如果不治疗可能会发生什么、以及如何最好地控制或管理这种疾病的看法。样本大小——毫无疑问,这是每个习惯于看到更大数字的读者心中的一个问题——是由一种先验分析方法决定的,这种方法导致了招募,直到在这些对话中没有出现新的主题。有些误解是令人震惊的。许多患者对关节炎原因的(错误)理解,他们对疼痛随时间加重的预期,以及他们对选择非手术治疗相关的潜在危害的信念,特别是,不能通过任何对我所知道的主题的证据的解释来证实。更重要的是,这些严重的误解似乎是主编的注释:在“编辑聚焦”中,我们的一位编辑对一篇我们认为特别重要且值得普遍关注的论文提供了简短的评论。在解释了我们的选择之后,我们将呈现“第5条”,在这条视频中,编辑将通过对“编辑聚焦”中这篇文章的一位作者的一对一采访,深入了解这一发现的背后。提交人证明,他本人及其直系亲属均无任何可能与所提交文章产生利益冲突的商业协会(如咨询公司、股票所有权、股权、专利/许可安排等)。所表达的观点是作者的观点,不反映CORR或骨关节外科医生协会的观点或政策。此评论引用的文章可在:DOI: 10.1097/CORR.0000000000000784。S. S. Leopold MD(;),临床骨科及相关研究,1600 Spruce Street, Philadelphia, PA 19013 USA, Email: sleopold@clinorthop.org
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Editor's Spotlight/Take 5: Misconceptions and the Acceptance of Evidence-based Nonsurgical Interventions for Knee Osteoarthritis. A Qualitative Study.
Many surgeons dislike or distrust methods-intensive research approaches like meta-analyses [14], and even experienced readers—including seasoned peer reviewers—head for the hills when it takes heavy computing power to grind data into answers [15], as is the case for studies using machine learning. So, let’s take a break this month from all that math, and luxuriate in the glow of some great qualitative research in this month’s Spotlight. Nary a decimal point or p value in sight. Did I hear someone say, “What’s qualitative research?” I’m not surprised. As far as I can recall, we’ve published only two papers [10, 12] in Clinical Orthopaedics and Related Research using qualitative or interview-based methods in the 7 years since I joined the team, and I’ve seen similarly sporadic deployment of these approaches in other leading generalinterest journals of our specialty [6, 8]. That’s too bad. The kinds of quantitative approaches that clinicians (and readers of clinical research) are most familiar with—case series, historically controlled studies, and even randomized trials—can tell us the what and the when, but they fall short on the why and the how. Specifically, they provide little or no insight into why our patients make the decisions they make, and how those patients perceive (and sometimes misunderstand) important facts about their own bodies. Facts that, in principle, their doctors have tried to explain. For these reasons, I’m excited to share a wonderful example of the genre in this month’s CORR from Dr. Jo-Anne Manski-Nankervis’s study group in Melbourne, Australia, which offers a number of penetrating insights into common misperceptions patients have about knee arthritis [2]. The authors, including first author, Samantha Bunzli PhD, performed indepth interviews with more than two dozen patients who were on a surgical waiting list to ascertain patients’ beliefs about what osteoarthritis is, what causes it, what may happen to it if left untreated, and how the condition can best be controlled or managed. The sample size—a question, no doubt, on every reader’s mind who is accustomed to seeing a larger number there—was determined by an a priori analytic approach that resulted in recruitment until no new themes emerged during these conversations. Some of the misunderstandings were staggering. Many patients’ (mis)understandings about the causes of their arthritis, their anticipation of worsening pain with time, and their beliefs about potential harms associated with choosing a non-surgical course, in particular, cannot be substantiated by any interpretation of the evidence on the topic of which I am aware. More importantly, those serious misapprehensions seem A note from the Editor-In-Chief: In “Editor’s Spotlight,” one of our editors provides brief commentary on a paper we believe is especially important and worthy of general interest. Following the explanation of our choice, we present “Take 5,” in which the editor goes behind the discovery with a oneon-one interview with an author of the article featured in “Editor’s Spotlight.” The author certifies that neither he, nor any members of his immediate family, have any commercial associations (such as consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article. The opinions expressed are those of the writer, and do not reflect the opinion or policy of CORR or The Association of Bone and Joint Surgeons. This comment refers to the article available at: DOI: 10.1097/CORR.0000000000000784. S. S. Leopold MD (✉), Clinical Orthopaedics and Related Research, 1600 Spruce Street, Philadelphia, PA 19013 USA, Email: sleopold@clinorthop.org
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