促炎细胞因子在桥本甲状腺炎相关精神疾病中的作用

Q4 Medicine
P. Sobolevskaia, A. N. Gvozdeckii, I. Kudryavtsev, V. Chereshnev, L. P. Сhurilov
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引用次数: 0

摘要

精神障碍往往伴随着自身免疫性疾病,例如,自1949年以来,人们已经知道了“黏液性水肿性疯狂”,这是一种由甲状腺功能减退引起的精神病。甲状腺功能减退症最常见的原因是桥本氏自身免疫性甲状腺炎。另一种与自身免疫性甲状腺炎相关的神经精神疾病桥本脑病也是已知的。这是一种中枢神经系统的严重功能障碍,其发病机制与激素紊乱无关。细胞因子是炎症的调节者和参与者,包括自身免疫。当然,当我们谈论高浓度细胞因子时,我们指的是全身性炎症。细胞因子在健康状态或疾病正常急性期反应范围内的微小或中等波动不能从二元内分泌逻辑的角度来解释。在中枢神经系统中,细胞因子能够影响系统调节功能的神经内分泌控制。同样重要的是,神经胶质细胞(星形胶质细胞、小胶质细胞)能够产生许多细胞因子,并能影响神经元并产生行为改变。此外,CNS自身之外的许多细胞因子作用于迷走神经传入事件并通过它们向CNS传递信息,影响其状态和功能的能力已被证实。我们有理由认为,细胞因子水平的微小波动也可能影响中枢神经系统的状态和功能。该研究的目的是调查甲状腺炎患者的细胞因子水平;甲状腺炎伴精神障碍患者;在一群健康的个体中;并评价细胞因子水平对临床表现的影响。甲状腺炎合并精神障碍患者CCL20/MIP3α、IL-13、IL-2、IL-27、IL-5水平显著高于其他组。同时,精神障碍的临床表现与细胞因子水平无正相关关系。一些细胞因子水平与游离三碘甲状腺原氨酸水平以及抗甲状腺抗体水平呈正相关。与自身免疫性甲状腺炎相关的精神障碍可能与细胞因子谱的变化有关,并且是神经炎症的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of proinflammatory cytokines in Hashimoto's thyroiditis associated with psychiatric disorders
Mental disorders often accompany autoimmune diseases, for example, since 1949 it has been known about “myxedematous madness”, a psychosis caused by hypothyroidism. The most common cause of hypothyroidism is Hashimoto's autoimmune thyroiditis. It is also known about another neuropsychiatric disorder associated with autoimmune thyroiditis, Hashimoto's encephalopathy. It is a severe dysfunction of the central nervous system, the pathogenesis of which is not associated with hormonal disorders. Cytokines are regulators and participants of inflammation, including autoimmune. Certainly, when we are talking about high concentrations cytokines, we mean systemic inflammation. The minimal or mediocre fluctuations in cytokines within the ranges that are characteristic of healthy status or normergic acute phase response in disease cannot be interpreted from the point of view of binary endocrinological logic. In the CNS, cytokines are able to influence on the neuroendocrine control of systemically regulated functions. It is also important that glial cells (astroglia, microglia) are capable of producing a number of cytokines and can affect neurons and develop behavioral changes. In addition, the ability of a number of cytokines outside the CNS itself to act on vagal afferents and through them to convey information to the CNS, affecting its state and functions, has been proven. It is reasonable to assume that minimal fluctuations in cytokine levels may also affect the state and function of the CNS. The aim of the study was to investigate the levels of cytokines in patients with thyroiditis; in patients with thyroiditis associated with mental disorders; in a group of healthy individuals; and evaluate the effect of cytokine levels on clinical manifestations. In the group of patients with thyroiditis and mental disorders, the levels of CCL20/MIP3α, IL-13, IL-2, IL-27, IL-5 were significantly higher than in other groups. At the same time, no positive correlation was found between the clinical manifestations of mental disorders and the levels of cytokines. A positive correlation was found between the levels of some cytokines and free triiodothyronine, as well as the level of antithyroid antibodies. Mental disorders associated with autoimmune thyroiditis may be associated with changes in the cytokine profile and result from neuroinflammation.
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来源期刊
Medical Immunology (Russia)
Medical Immunology (Russia) Medicine-Immunology and Allergy
CiteScore
0.70
自引率
0.00%
发文量
88
审稿时长
12 weeks
期刊介绍: The journal mission is to promote scientific achievements in fundamental and applied immunology to various medical fields, the publication of reviews, lectures, essays by leading domestic and foreign experts in the field of fundamental and experimental immunology, clinical immunology, allergology, immunodiagnostics and immunotherapy of infectious, allergy, autoimmune diseases and cancer.
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