非大豆异黄酮(葛根)对绝经期妇女Kupperman指数症状严重程度评分的影响

IF 0.2 Q4 PHARMACOLOGY & PHARMACY
M. Tangkas, W. Ngartjono, A. Hidayat, L. Farida
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引用次数: 0

摘要

引言:绝经是由雌激素水平下降而引起的各种症状所定义的。以富含植物雌激素的食物或补品为基础的治疗,特别是异黄酮,具有雌激素作用的植物来源化合物,最近变得相当流行。本研究旨在了解非大豆异黄酮补充剂对女性更年期症状的效果。方法:在一项分析性双盲随机临床试验(RCT)中,26名绝经妇女每天服用67.5 mg非大豆异黄酮,25名绝经妇女每天服用安慰剂,持续12周。纳入标准为:(1)随机对照试验,(2)围绝经期或绝经后出现更年期症状的妇女,(3)口服非大豆异黄酮干预。在研究开始前和研究结束时对患者进行基于Kupperman指数(KI)问卷的症状严重程度评分(SSS)。采用SPSS (Statistical Package for Social Sciences)软件对调查结果进行分析。结果:治疗组与对照组SSS评分差异有统计学意义(p = 0.000)。每天摄入67.5毫克非大豆异黄酮的女性,分别减少了92.3%、77%和53.8%的肌痛、疲劳和潮热。临床意义评分采用相对风险降低(relative risk reduction, RRR)。肌痛症状(76.6%)、疲劳(55.7%)、潮热(39.2%)和SSS(68.7%)导致显著的RRR值。结论:与安慰剂相比,异黄酮没有带来Kupperman指数的显著变化,但显著改善了更年期妇女的症状严重程度评分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of Non-Soy Isoflavone (Pueraria phaseoloides) on The Symptoms Severity Scoring by Kupperman Index in Menopausal Women
Introduction: Menopause is defined by a decline in estrogen levels, which causes various symptoms. Treatments based on foods or supplements enriched in phytoestrogens, notably isoflavones, plant-derived compounds with estrogenic effects, have recently become quite popular. This study aims to see how effective non-soy isoflavone supplementation is for menopausal symptoms in women. Methods: 26 menopausal women were given 67.5 mg of non-soy isoflavone, and 25 menopausal women were given a placebo daily for 12 weeks in an analytical double-blind, randomized clinical trial (RCT). Inclusion criteria were (1) RCT, (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral non-soy isoflavone. Symptoms Severity Score (SSS) based on the Kupperman index (KI) questionnaire was administered to the patients before starting and at the end of the study. The Statistical Package for Social Sciences (SPSS) software was used to analyze the responses. Results: The difference in SSS scores between the treatment and control groups was significant (p = 0.000). Women receiving 67.5 mg of non-soy isoflavone daily, reduced myalgia, fatigue, and hot flushes by 92.3%, 77%, and 53.8%, respectively. For clinical significance rating, relative risk reduction (RRR) is used. A significant RRR value resulted from myalgia symptoms (76.6%), fatigue (55.7%), hot flushes (39.2%), and SSS (68.7%). Conclusion: Isoflavones did not bring a significant change in Kupperman Index compared to placebo but provided significantly improved Symptoms Severity Scoring in menopausal women.
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