Andi Cahyadi, Esthy Poespitaningtyas, Diah Kusuma Arumsari, Maria Christina Shanty Larasati, Mia Ratwita Andarsini, I Dewa Gede Ugrasena
{"title":"东爪哇儿童血液恶性肿瘤和实体瘤的地区差异","authors":"Andi Cahyadi, Esthy Poespitaningtyas, Diah Kusuma Arumsari, Maria Christina Shanty Larasati, Mia Ratwita Andarsini, I Dewa Gede Ugrasena","doi":"10.55561/ajhr.v2i1.71","DOIUrl":null,"url":null,"abstract":"Introduction: The prevalence of childhood cancer in East Java is unevenly associated with differences in exposure to carcinogens in urban-industrial areas, agricultural chemicals, industrial waste along the river, and socio-culture. However, there are no data on regional variations in childhood cancer in East Java. We describe the regional variation of hematological malignancies and solid tumors in East Java.\nMaterial and Methods: The study was conducted by cross-sectional on children with cancer aged <18 years in dr. Soetomo General Academic Hospital in 2014-2015. The data evaluated were gender, age, and cancer type (hematological malignancy and solid tumor). They came from Mataraman, Madura Island, industrial-urban areas (Surabaya-Sidoarjo-Gresik), and Tapal Kuda. We used the Chi-square test and Logistic Regression for data analysis (p<0.05 for two-tailed test).\nResults: During the study period, there were 353 children with cancer, consisting of 56.9% hematological malignancies and 43.1% solid tumors: 60.9% boys, and 82.4% aged <10 years. Hematological malignancies in industries-urban areas are more numerous than in Mataraman, Madura Island, and Tapal Kuda; 67.8%, 52.8%, 47.2%, and 50.9%, respectively (p=0.031). Hematologic malignancies were also more common in aged <10 years (60.5% vs 40.3%; p=0.004 OR=2.265; 95% CI=1.295-3.362) and Javanese race (p=0.025; OR=3.257; 95% CI=1.121-5.263). Children in industrial-urban areas had more hematological malignancies than Mataraman (p=0.027; OR=2.353; 95% CI=1.101-5.030) also Tapal Kuda (p=0.015; OR=1.881; 95% CI=1.132-3.124) and Madura Island (p=0.032; OR=2.033; 95% CI=1.064-3.882).\nConclusion: Hematological malignancies in industry and urban areas are more numerous than Mataraman, Madura Island, and Tapal Kuda area. Solid tumors were mostly found on Madura Island.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Region Variation of Hematological Malignancies and Solid Tumors in Children in East Java\",\"authors\":\"Andi Cahyadi, Esthy Poespitaningtyas, Diah Kusuma Arumsari, Maria Christina Shanty Larasati, Mia Ratwita Andarsini, I Dewa Gede Ugrasena\",\"doi\":\"10.55561/ajhr.v2i1.71\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: The prevalence of childhood cancer in East Java is unevenly associated with differences in exposure to carcinogens in urban-industrial areas, agricultural chemicals, industrial waste along the river, and socio-culture. However, there are no data on regional variations in childhood cancer in East Java. We describe the regional variation of hematological malignancies and solid tumors in East Java.\\nMaterial and Methods: The study was conducted by cross-sectional on children with cancer aged <18 years in dr. Soetomo General Academic Hospital in 2014-2015. The data evaluated were gender, age, and cancer type (hematological malignancy and solid tumor). They came from Mataraman, Madura Island, industrial-urban areas (Surabaya-Sidoarjo-Gresik), and Tapal Kuda. We used the Chi-square test and Logistic Regression for data analysis (p<0.05 for two-tailed test).\\nResults: During the study period, there were 353 children with cancer, consisting of 56.9% hematological malignancies and 43.1% solid tumors: 60.9% boys, and 82.4% aged <10 years. Hematological malignancies in industries-urban areas are more numerous than in Mataraman, Madura Island, and Tapal Kuda; 67.8%, 52.8%, 47.2%, and 50.9%, respectively (p=0.031). Hematologic malignancies were also more common in aged <10 years (60.5% vs 40.3%; p=0.004 OR=2.265; 95% CI=1.295-3.362) and Javanese race (p=0.025; OR=3.257; 95% CI=1.121-5.263). Children in industrial-urban areas had more hematological malignancies than Mataraman (p=0.027; OR=2.353; 95% CI=1.101-5.030) also Tapal Kuda (p=0.015; OR=1.881; 95% CI=1.132-3.124) and Madura Island (p=0.032; OR=2.033; 95% CI=1.064-3.882).\\nConclusion: Hematological malignancies in industry and urban areas are more numerous than Mataraman, Madura Island, and Tapal Kuda area. Solid tumors were mostly found on Madura Island.\",\"PeriodicalId\":8534,\"journal\":{\"name\":\"Asian Journal of Pharmaceutical Research and Health Care\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Pharmaceutical Research and Health Care\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55561/ajhr.v2i1.71\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmaceutical Research and Health Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55561/ajhr.v2i1.71","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
东爪哇儿童癌症患病率与城市工业区致癌物暴露、农业化学品、沿河工业废物和社会文化的差异有不均匀的关系。然而,没有关于东爪哇儿童癌症区域差异的数据。我们描述了血液恶性肿瘤和实体瘤在东爪哇的区域变化。材料与方法:采用横断面法对2014-2015年dr. Soetomo综合学术医院年龄<18岁的癌症患儿进行研究。评估的数据包括性别、年龄和癌症类型(血液恶性肿瘤和实体瘤)。他们来自Mataraman, Madura岛,工业城市地区(Surabaya-Sidoarjo-Gresik)和Tapal Kuda。资料分析采用卡方检验和Logistic回归(双侧检验p<0.05)。结果:研究期间,儿童癌症353例,其中血液病恶性占56.9%,实体瘤占43.1%,男孩占60.9%,年龄<10岁占82.4%。工业-城市地区的恶性血液病比Mataraman、Madura岛和Tapal Kuda多;分别为67.8%、52.8%、47.2%和50.9% (p = 0.031)。血液系统恶性肿瘤在小于10岁的人群中也更为常见(60.5% vs 40.3%;p = 0.004 = 2.265;95% CI=1.295-3.362)和爪哇人种(p=0.025;或= 3.257;95% CI = 1.121 - -5.263)。工业-城市地区儿童血液系统恶性肿瘤发生率高于Mataraman (p=0.027;或= 2.353;95% CI=1.101-5.030)和Tapal Kuda (p=0.015;或= 1.881;95% CI=1.132-3.124)和Madura Island (p=0.032;或= 2.033;95% CI = 1.064 - -3.882)。结论:工业和城市地区的恶性血液病发病率高于马塔拉曼、马杜拉岛和塔帕尔库达地区。实体瘤主要在马杜拉岛发现。
Region Variation of Hematological Malignancies and Solid Tumors in Children in East Java
Introduction: The prevalence of childhood cancer in East Java is unevenly associated with differences in exposure to carcinogens in urban-industrial areas, agricultural chemicals, industrial waste along the river, and socio-culture. However, there are no data on regional variations in childhood cancer in East Java. We describe the regional variation of hematological malignancies and solid tumors in East Java.
Material and Methods: The study was conducted by cross-sectional on children with cancer aged <18 years in dr. Soetomo General Academic Hospital in 2014-2015. The data evaluated were gender, age, and cancer type (hematological malignancy and solid tumor). They came from Mataraman, Madura Island, industrial-urban areas (Surabaya-Sidoarjo-Gresik), and Tapal Kuda. We used the Chi-square test and Logistic Regression for data analysis (p<0.05 for two-tailed test).
Results: During the study period, there were 353 children with cancer, consisting of 56.9% hematological malignancies and 43.1% solid tumors: 60.9% boys, and 82.4% aged <10 years. Hematological malignancies in industries-urban areas are more numerous than in Mataraman, Madura Island, and Tapal Kuda; 67.8%, 52.8%, 47.2%, and 50.9%, respectively (p=0.031). Hematologic malignancies were also more common in aged <10 years (60.5% vs 40.3%; p=0.004 OR=2.265; 95% CI=1.295-3.362) and Javanese race (p=0.025; OR=3.257; 95% CI=1.121-5.263). Children in industrial-urban areas had more hematological malignancies than Mataraman (p=0.027; OR=2.353; 95% CI=1.101-5.030) also Tapal Kuda (p=0.015; OR=1.881; 95% CI=1.132-3.124) and Madura Island (p=0.032; OR=2.033; 95% CI=1.064-3.882).
Conclusion: Hematological malignancies in industry and urban areas are more numerous than Mataraman, Madura Island, and Tapal Kuda area. Solid tumors were mostly found on Madura Island.