肿瘤相关成纤维细胞的机制研究及在乳腺癌中的临床应用

国际肿瘤学杂志 Pub Date : 2019-06-18 DOI:10.3760/CMA.J.ISSN.1673-422X.2019.06.009

Jia-Hui Ye

{"title":"肿瘤相关成纤维细胞的机制研究及在乳腺癌中的临床应用","authors":"Jia-Hui Ye","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.06.009","DOIUrl":null,"url":null,"abstract":"The occurrence and development of breast cancer is a complex process which referring to multi-factor interaction. During this process, cancer-associated fibroblasts (CAFs) secrect various growth factors and cytokines to promote the tumor progression, angiogenesis, metastasis, drug resistance. Meanwhile, it can also judge the prognosis of patients through the expression of CAFs. CAFs may offer a new therapeutic strategy against breast cancer. \n \n \nKey words: \nCancer-associated fibroblasts; Breast neoplasms; Tumor microenvironment; Biomarkers; Prognosis","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"117 1","pages":"358-361"},"PeriodicalIF":0.0000,"publicationDate":"2019-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mechanism study of cancer-associated fibroblasts and clinical application in breast cancer\",\"authors\":\"Jia-Hui Ye\",\"doi\":\"10.3760/CMA.J.ISSN.1673-422X.2019.06.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The occurrence and development of breast cancer is a complex process which referring to multi-factor interaction. During this process, cancer-associated fibroblasts (CAFs) secrect various growth factors and cytokines to promote the tumor progression, angiogenesis, metastasis, drug resistance. Meanwhile, it can also judge the prognosis of patients through the expression of CAFs. CAFs may offer a new therapeutic strategy against breast cancer. \\n \\n \\nKey words: \\nCancer-associated fibroblasts; Breast neoplasms; Tumor microenvironment; Biomarkers; Prognosis\",\"PeriodicalId\":16120,\"journal\":{\"name\":\"国际肿瘤学杂志\",\"volume\":\"117 1\",\"pages\":\"358-361\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际肿瘤学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.06.009\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际肿瘤学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.06.009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

乳腺癌的发生发展是一个多因素相互作用的复杂过程。在此过程中，癌相关成纤维细胞分泌多种生长因子和细胞因子，促进肿瘤的进展、血管生成、转移和耐药。同时，还可以通过caf的表达来判断患者的预后。CAFs可能提供一种新的治疗乳腺癌的策略。关键词:癌症相关成纤维细胞;乳腺肿瘤;肿瘤微环境;生物标志物;预后

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mechanism study of cancer-associated fibroblasts and clinical application in breast cancer

The occurrence and development of breast cancer is a complex process which referring to multi-factor interaction. During this process, cancer-associated fibroblasts (CAFs) secrect various growth factors and cytokines to promote the tumor progression, angiogenesis, metastasis, drug resistance. Meanwhile, it can also judge the prognosis of patients through the expression of CAFs. CAFs may offer a new therapeutic strategy against breast cancer. Key words: Cancer-associated fibroblasts; Breast neoplasms; Tumor microenvironment; Biomarkers; Prognosis

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

国际肿瘤学杂志

自引率

0.00%

发文量

12123

期刊介绍：