原发性肾病综合征患儿足细胞修复的表观遗传标记

S. L. Morozov, V. Dlin, V. Voinova, A. V. Smirnova, O. R. Piruzieva
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引用次数: 0

摘要

在肾小球损伤的研究模式方面,特发性肾病综合征是最突出的例子。在世界范围内,肾病综合征是一种具有社会意义的疾病,被认为是儿童时期最常见的肾小球疾病之一,可导致慢性肾病的发展,并在疾病进展的情况下形成终末期慢性肾衰竭。本文介绍了我们自己的研究数据,并讨论了原发性肾病综合征患儿足细胞修复的表观遗传标记。我们注意到,在患有类固醇敏感型肾病综合征的患者中,WT1(足细胞转录因子)和NPHS1(编码nephrin的基因,nephrin是一种跨膜蛋白,是足细胞缝隙隔膜的结构成分)基因的表达明显高于对照组和类固醇抗性肾病综合征患儿。通过确定肾小球病理过程的分期和/或严重程度的标记物,获得的数据为发展个性化方法来管理原发性肾病综合征儿童开辟了前景。目前,基因组和后基因组技术越来越多地应用于临床实践,这将最终导致基于创新技术的个性化诊断面板的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetic markers of podocyte repair in children with primary nephrotic syndrome
In terms of a glomerular injury research model, idiopathic nephrotic syndrome is the most prominent example. Worldwide, nephrotic syndrome is a socially significant disease and is considered one of the most common glomerulopathies in childhood, leading to the development of chronic kidney disease, and in the case of progression of the disease, to the formation of terminal chronic renal failure. This article presents data from our own study and discusses epigenetic markers of podocyte repair in children with primary nephrotic syndrome. We noted that in patients with steroid-sensitive variants of nephrotic syndrome, the expression of the WT1 (podocyte transcription factor) and NPHS1 (the gene encoding nephrin — a transmembrane protein that is a structural component of the slit diaphragm of the podocyte) genes is significantly higher than in the control group and in children with steroid resistant nephrotic syndrome. The data obtained open up prospects for the development of a personalized approach to the management of children with primary nephrotic syndrome by determining the markers of the staging and/or severity of the pathological process occurring in the glomeruli. Currently, genomic and post-genomic technologies are increasingly being used in clinical practice, which will eventually lead to the development of personalized diagnostic panels based on innovative technologies.
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