结直肠癌伴同步可切除肝转移患者的术前或术后化疗?

Q4 Medicine

Nowotwory Pub Date : 2018-01-01 DOI:10.5603/2018.0044

R. Stec

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引用次数: 0

摘要

目前，对于结直肠同步可切除肝转移患者术前化疗的应用尚无明确的科学数据。在分析术前化疗的毒性及围手术期并发症、术前和术后化疗的疗效、术前化疗使用的疑虑三个问题的基础上，提出以下反对术前化疗在上述临床情况下使用的观点。综上所述，大多数科学数据都反对术前化疗，因为它会引起明显的不良反应(肝毒性和随之而来的术后并发症)，而不能显著提高生存率。因此，在这组患者中，术后化疗似乎是更理想的治疗方法。

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Pre- or postoperative chemotherapy in patients with colorectal cancer with synchronous, resectable liver metastases?

At the moment, there is no clear scientific data on the use of preoperative chemotherapy in patients with colorectal, synchronous, resectable liver metastases. Below arguments are presented against the use of preoperative chemotherapy in the above clinical situation, based on an analysis of three issues: the toxicity of preoperative chemotherapy and associated perioperative complications, the efficacy of pre- and postoperative chemotherapy, doubts related to the use of preoperative chemotherapy. To summarise, most scientific data is against preoperative chemotherapy as it causes significant adverse effects (hepatotoxicity and consequent postoperative complications) without a significant improvement in survival rates. Therefore, postoperative chemotherapy in this group of patients seems to be the more optimal treatment.

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来源期刊

Nowotwory Medicine-Oncology

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： NOWOTWORY Journal of Oncology publishes papers which cover all aspects of oncology but concentrates on clinical studies, both research orientated and treatment orientated, rather than on laboratory studies. Contributions are also welcomed from the fields of epidemiology, tumor pathology, radiobiology and radiation physics.