T. Kametani, C. Seino, K. Yamaki, S. Shibuya*, K. Fukumoto*, K. Kigasawa, F. Satoh, M. Hiiragi, T. Hayasaka
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Studies on the syntheses of heterocyclic compounds. Part CCCLXXXVI. Alternative total syntheses of galanthamine and N-benzylgalanthamine iodide
Alternative total syntheses of galanthamine (Ia) and N-benzylgalanthamine iodide (VIa) were carried out by phenolic oxidative reactions of the corresponding amides (IIIf and e). Both (–)-and (±)-galanthamine showed analgesic activity comparable to that of morphine.
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