伪蝶蛋白A - f苷元的合成

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2012-09-01 DOI:10.1055/S-0032-1316643

John P. Cooksey, P. Kocieňski, Arndt W. Schmidt, T. Snaddon, C. Kilner

引用次数: 12

摘要

由3-甲基儿茶酚合成伪鸟蛋白a - f苷元的特点是:(a)使用不对称的Ireland-Claisen和芳基Claisen重排来安装分子中存在的四个立体中心中的三个;(b)采用闭合环复分解和阳离子环化反应为关键步骤的a→AB→ABC环化策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Synthesis of the Pseudopterosin A–F Aglycone

The synthesis of the pseudopterosin A–F aglycone from 3-methylcatechol features (a) the use of asymmetric Ireland–Claisen and aryl Claisen rearrangements to install three of the four stereocentres present in the molecule and (b) an A→AB→ABC annulation strategy using ring-closing metathesis and cationic cyclisation reactions as the key steps.

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.