肝病患者纤维蛋白原结合唾液水平的检测及其临床意义

中国医师进修杂志 Pub Date : 2000-08-15 DOI:10.3760/CMA.J.ISSN.1673-4904.2000.08.010

Jian Li, Yu-gui Zhou, Guoyong Ding, Zheng Zhu

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引用次数: 0

摘要

目的:探讨肝脏疾病患者纤维蛋白原结合唾液酸水平的临床意义。方法:用饱和硫酸铵沉淀法纯化柠檬酸血浆中的纤维蛋白原。用硫代巴比妥酸法测定22例对照组和113例肝脏患者纤维蛋白原结合唾液酸水平。结果:肝硬化组患者血清血清素水平明显高于对照组及其他肝病组(P0.01)。凝血酶时间与纤维蛋白原结合唾液酸含量之间存在相关性。纤维蛋白单体的聚合与纤维蛋白原结合的唾液酸成反比。结论:纤维蛋白原结合唾液酸水平可作为获得性纤维蛋白异常血症的诊断指标。

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DETECTION AND ITS CLINICAL SIGNIFICANCE OF FIBRINOGEN-BOUND SIALIC LEVELS IN PATIENTS WITH LIVER DISEASE

Objective:To explore the clinical significance of fibrinogen-bound sialic acid levels in patients with liver disease.Methods:Fibrinogen was purified by precipitation from citrated plasma by saturated ammonium sulplvate.Fibrinogen-bound sialic acid levels with 22 controls and 113 liver patients were assayed by the thiobarbituric acid method.Results:The level of the patients with liver cirrhosis was significantly higher than that of the controls and others liver disease group (P0.01).In addition there was relationship between the thrombin time and fibrinogen-bound sialic acid contents.Poly merization of fibrin monomer was inverse ratio with fibrinogen-bound sialic acid.Conclusion:It suggests that fibrinogen-bound sialic acid levels may be diagnostic index acquired dysfibrinogenaemia.

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中国医师进修杂志

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