Yuriko Otake-Kasamoto, H. Kayama, T. Kishikawa, S. Shinzaki, T. Tashiro, Takahiro Amano, M. Tani, T. Yoshihara, Bo Li, Haruka Tani, Li Liu, Akio Hayashi, D. Okuzaki, D. Motooka, S. Nakamura, Y. Okada, H. Iijima, K. Takeda, T. Takehara
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Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response
This study shows that Crohn’s disease–associated microbiota generate lysophosphatidylserines that promote Th1 responses by fueling glycolysis. Lysophosphatidylserine-induced aggravation of colitis is prevented by P2y10 deficiency in CD4+ T cells, demonstrating that dysbiotic microbiota-derived LysoPS exacerbates colitis by modulating Th1 cell metabolism.
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