Gabriel Chodick , Moran Almog , Shai Ashkenazi , Tal Sella
{"title":"轮状病毒免疫与1型糖尿病:一项巢式病例对照研究","authors":"Gabriel Chodick , Moran Almog , Shai Ashkenazi , Tal Sella","doi":"10.1016/j.pid.2014.12.004","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The objective of the present nested case–control study was to assess whether rotavirus vaccination is associated with reduced risk of </span>Type 1 diabetes mellitus<span> (T1DM). Using clinical database of a large health organization in Israel, we identified all incident cases of T1DM that were born during the period spanning January 2008 to June 2010, and diagnosed before March 2012. For each case, we selected up to three control individuals without T1DM that were individually matched on the exact date of birth. A total of 16 eligible T1DM cases were detected and 45 matched controls. After adjusting to residence area in Israel, the odds ratio for T1DM associated with full vaccination against rotavirus was 7.38 (95%: 1.19–45.62, P = 0.032). The results of the present study do not support the conclusion that childhood immunization with </span></span>rotavirus vaccine is associated with reduced risk of T1DM.</p></div>","PeriodicalId":19984,"journal":{"name":"Pediatric Infectious Disease","volume":"6 4","pages":"Pages 147-149"},"PeriodicalIF":0.0000,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pid.2014.12.004","citationCount":"1","resultStr":"{\"title\":\"Rotavirus immunization and type 1 diabetes mellitus: A nested case–control study\",\"authors\":\"Gabriel Chodick , Moran Almog , Shai Ashkenazi , Tal Sella\",\"doi\":\"10.1016/j.pid.2014.12.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>The objective of the present nested case–control study was to assess whether rotavirus vaccination is associated with reduced risk of </span>Type 1 diabetes mellitus<span> (T1DM). Using clinical database of a large health organization in Israel, we identified all incident cases of T1DM that were born during the period spanning January 2008 to June 2010, and diagnosed before March 2012. For each case, we selected up to three control individuals without T1DM that were individually matched on the exact date of birth. A total of 16 eligible T1DM cases were detected and 45 matched controls. After adjusting to residence area in Israel, the odds ratio for T1DM associated with full vaccination against rotavirus was 7.38 (95%: 1.19–45.62, P = 0.032). The results of the present study do not support the conclusion that childhood immunization with </span></span>rotavirus vaccine is associated with reduced risk of T1DM.</p></div>\",\"PeriodicalId\":19984,\"journal\":{\"name\":\"Pediatric Infectious Disease\",\"volume\":\"6 4\",\"pages\":\"Pages 147-149\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.pid.2014.12.004\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Infectious Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212832815000028\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212832815000028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Rotavirus immunization and type 1 diabetes mellitus: A nested case–control study
The objective of the present nested case–control study was to assess whether rotavirus vaccination is associated with reduced risk of Type 1 diabetes mellitus (T1DM). Using clinical database of a large health organization in Israel, we identified all incident cases of T1DM that were born during the period spanning January 2008 to June 2010, and diagnosed before March 2012. For each case, we selected up to three control individuals without T1DM that were individually matched on the exact date of birth. A total of 16 eligible T1DM cases were detected and 45 matched controls. After adjusting to residence area in Israel, the odds ratio for T1DM associated with full vaccination against rotavirus was 7.38 (95%: 1.19–45.62, P = 0.032). The results of the present study do not support the conclusion that childhood immunization with rotavirus vaccine is associated with reduced risk of T1DM.
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