Activités physiques, sédentarité, comorbidités et arthrose

Osteoarthritis (OA) is a global disease of all the structures of a joint. It is heterogeneous due to the different OA phenotypes. If biomechanical constraints with multiples factors can cause damage to the cartilage, the extra cellular matrix and the chondrocyte, physical inactivity and especially a sedentary lifestyle are major risks in our society for the development of OA. Indeed, sedentary lifestyle may be responsible for early, subclinical damage to the cartilage due to metabolic inflexibility and insulin resistance that it causes, well before the classic metabolic complications of related complications (obesity, cardio-vascular diseases, dyslipidemia, type 2 diabetes, atherosclerosis) which will lead to an increased risk of mortality during the course of OA. The prevention of OA without medication relies not only on physical activity but also on the reduction of sedentary periods and on the sedentary behavior. The non pharmacolological prevention of osteoarthritis relies not only on regular physical activities but also on the reduction of long periods of sedentarity during the day and on the change in the sedentary behavior.