身体活动,久坐的生活方式,合并症和骨关节炎

Bernard Fouquet, Pauline Jaume-Guichard
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引用次数: 2

摘要

骨关节炎(OA)是一种涉及关节所有结构的全球性疾病。由于OA表型不同,它是异质的。如果多种因素的生物力学约束可导致软骨、细胞外基质和软骨细胞的损伤,那么缺乏运动,特别是久坐的生活方式是我们社会中OA发展的主要风险。事实上,久坐不动的生活方式可能会导致早期的亚临床软骨损伤,这是由于代谢不灵活和胰岛素抵抗引起的,远早于相关并发症的典型代谢并发症(肥胖、心血管疾病、血脂异常、2型糖尿病、动脉粥样硬化),这将导致OA期间死亡风险的增加。不使用药物预防OA不仅依赖于身体活动,还依赖于减少久坐时间和久坐行为。骨关节炎的非药物预防不仅依赖于规律的体育活动,还依赖于减少白天久坐的时间和改变久坐的行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Activités physiques, sédentarité, comorbidités et arthrose

Osteoarthritis (OA) is a global disease of all the structures of a joint. It is heterogeneous due to the different OA phenotypes. If biomechanical constraints with multiples factors can cause damage to the cartilage, the extra cellular matrix and the chondrocyte, physical inactivity and especially a sedentary lifestyle are major risks in our society for the development of OA. Indeed, sedentary lifestyle may be responsible for early, subclinical damage to the cartilage due to metabolic inflexibility and insulin resistance that it causes, well before the classic metabolic complications of related complications (obesity, cardio-vascular diseases, dyslipidemia, type 2 diabetes, atherosclerosis) which will lead to an increased risk of mortality during the course of OA. The prevention of OA without medication relies not only on physical activity but also on the reduction of sedentary periods and on the sedentary behavior. The non pharmacolological prevention of osteoarthritis relies not only on regular physical activities but also on the reduction of long periods of sedentarity during the day and on the change in the sedentary behavior.

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