异丙酚和氯胺酮对蜗牛滞海的兴奋作用

A.J Woodall , C.R McCrohan
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引用次数: 8

摘要

本研究比较了静脉麻醉药异丙酚和氯胺酮对动物行为和蜗牛停滞淋巴神经元活动的作用,特别是与临床观察到的兴奋作用有关。当注射到整个动物体内时,两种药物都没有引起完全麻醉。相反,异丙酚(10−5 M)和氯胺酮(10−7 M)增强了行为活动,表明兴奋作用。当在分离的中枢神经系统(CNS)上过量时,两个已确定的神经元,右足背1 (RPeD1)和内脏背4 (VD4)产生不同的效应。静息膜的性质基本未受影响。然而,超极化后RPeD1的尖峰明显减少,但VD4没有,有一些证据表明兴奋性增加。此外,异丙酚(10−7 M)改变了VD4的固有破裂特性(刺激后破裂)。这些结果表明,在某些静脉麻醉剂的作用中存在显著的兴奋成分,并可能在改变中枢神经系统的兴奋和破裂机制中发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Excitatory actions of propofol and ketamine in the snail Lymnaea stagnalis

This study compares the actions of the intravenous anaesthetics propofol and ketamine on animal behaviour and neuronal activity in the snail Lymnaea stagnalis, particularly in relation to excitatory effects observed clinically. When injected into the whole animal, neither agent induced total anaesthesia. Rather, behavioural activity was enhanced by propofol (10−5 M) and ketamine (10−7 M), indicating excitatory effects. When superfused over the isolated central nervous system (CNS), differential effects were produced in two identified neurons, right pedal dorsal 1 (RPeD1) and visceral dorsal 4 (VD4). Resting membrane properties were largely unaffected. However, spike after hyperpolarisation was significantly reduced in RPeD1, but not VD4, with some evidence of increased excitability. In addition, an intrinsic bursting property (post-stimulus burst) in VD4 was altered by propofol (10−7 M). The results suggest significant excitatory components in the actions of some intravenous anaesthetics, as well as a potential role in modifying excitation and bursting mechanisms in the CNS.

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