Correlation between Glycated Haemoglobin Values and the Lipid Profile in Type 2 Diabetic Patients

Background: To investigate the relationship between glycated haemoglobin (HbA1c) and the lipid profile in patients of type-2 diabetes. Methods: The study has been conducted on 32 patients of type 2 diabetes. These are patients diagnosed with Type 2 diabetes of age group between 30 and 70 years. Blood samples were collected after 12 hours of fasting where blood samples were drawn before and after a meal from the patients to measure levels of the sugar and lipids. Various biochemical assays were carried out including fasting plasma glucose (FPG), PPBG, HbA1c and lipid profile, along with the patient’s age, and gender. The method that has been used for doing these investigations is Kit Spinreact. Results: The study found that the participants have an increase in FBG, PPBG, HbA1C, TC, TG, VLDL-C and LDL-C, with a decrease in HDL-C concentrations in type 2 diabetic patients. The result showed a correlation of HbA1c with other variables. The HbA1c significantly correlated with FBG (r=0.531, P=0.000), PPBG (r= 0.699, P=0.000), Total Cholesterol (r= 0.339, P=0.006), Triglycerides (r=0.357, P=0.004), Low-density Lipoprotein (r=0.269, P=0.031) and Very low-density Lipoprotein (r=0.364, P=0.003) where it was not correlated with HDL (r=-0.182, P=0.149). Conclusion: The HbA1c was significantly associated with all variables (lipid profile) except HDL which did not reach the significant level. These findings suggest that HbA1c level can be used as a good parameter for predicting the lipid profile of type 2 diabetic patients.