{"title":"树突状细胞疫苗治疗多形性胶质母细胞瘤:临床经验及未来发展方向","authors":"J. Dejaegher, L. Solie, S. Vleeschouwer, S. Gool","doi":"10.1109/IARWISOCI.2014.7034631","DOIUrl":null,"url":null,"abstract":"Dendritic cell vaccination is an experimental treatment for malignant gliomas, and has been subject of a translational program for more than ten years in our center. In vitro research, animal models and clinical trials for relapsed and newly diagnosed patients have been conducted. In this paper, we give an overview of the mechanism and rationale of this treatment for brain cancer. We also briefly discuss recently updated results of our clinical trials. Finally, we mention strategies to select patients for this therapy and additional immunotherapeutic strategies to further enhance the antitumor immune responses.","PeriodicalId":93358,"journal":{"name":"Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation : the CHIC Project Workshop (IARWISOCI) : Athens, Greece, 3-4 November 2014. International Advanced Research Workshop on...","volume":"23 1","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"2015-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Dendritic cell vaccination for glioblastoma multiforme: Clinical experience and future directions\",\"authors\":\"J. Dejaegher, L. Solie, S. Vleeschouwer, S. Gool\",\"doi\":\"10.1109/IARWISOCI.2014.7034631\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Dendritic cell vaccination is an experimental treatment for malignant gliomas, and has been subject of a translational program for more than ten years in our center. In vitro research, animal models and clinical trials for relapsed and newly diagnosed patients have been conducted. In this paper, we give an overview of the mechanism and rationale of this treatment for brain cancer. We also briefly discuss recently updated results of our clinical trials. Finally, we mention strategies to select patients for this therapy and additional immunotherapeutic strategies to further enhance the antitumor immune responses.\",\"PeriodicalId\":93358,\"journal\":{\"name\":\"Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation : the CHIC Project Workshop (IARWISOCI) : Athens, Greece, 3-4 November 2014. International Advanced Research Workshop on...\",\"volume\":\"23 1\",\"pages\":\"1-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-02-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation : the CHIC Project Workshop (IARWISOCI) : Athens, Greece, 3-4 November 2014. International Advanced Research Workshop on...\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/IARWISOCI.2014.7034631\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation : the CHIC Project Workshop (IARWISOCI) : Athens, Greece, 3-4 November 2014. International Advanced Research Workshop on...","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/IARWISOCI.2014.7034631","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Dendritic cell vaccination for glioblastoma multiforme: Clinical experience and future directions
Dendritic cell vaccination is an experimental treatment for malignant gliomas, and has been subject of a translational program for more than ten years in our center. In vitro research, animal models and clinical trials for relapsed and newly diagnosed patients have been conducted. In this paper, we give an overview of the mechanism and rationale of this treatment for brain cancer. We also briefly discuss recently updated results of our clinical trials. Finally, we mention strategies to select patients for this therapy and additional immunotherapeutic strategies to further enhance the antitumor immune responses.
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