COVID-19中的维生素D

R. Devi, Niangngaih Lian, T. O. Singh, Chungkham Rebika Devi
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摘要

严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起冠状病毒病2019 (COVID-19),临床结果从无症状到严重疾病,甚至死亡。它对全球医疗体系构成了可怕的挑战。一些观察性和临床试验报告,维生素D缺乏会导致急性呼吸窘迫综合征。病死率随着年龄和合并症的增加而增加,这两者都与维生素D水平下降有关。因此,本研究旨在研究25(OH)维生素D在RT-PCR阳性COVID-19病例和RT-PCR阴性对照中的患病率。这是在曼尼普尔贾瓦哈拉尔·尼赫鲁医学科学研究所进行的一项基于医院的横断面研究,在2年的时间里,对88例RT-PCR阳性的Covid-19病例和88例Covid-19阴性的对照进行研究。采用Liaison 25(OH)维生素D总化学发光法(CLIA)对样品进行分析。在本研究中,COVID-19阳性患者血浆25(OH)维生素D水平(中位数为28±20.47)低于COVID-19阴性对照组(中位数为33.50±10.66),具有统计学意义(p-0.018)。与Covid-19阴性对照相比,Covid-19阳性病例25(OH)维生素D缺乏的数量分别为46(52.3%)和30(34%),差异有统计学意义(p-0.015)。COVID-19阳性患者血浆25(OH)维生素D水平不理想的趋势更高,这可能是COVID-19感染住院风险高的原因。这一发现很重要,因为它可以确定高危人群,并有助于采取干预措施,降低与COVID-19感染相关的住院风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin D in COVID-19
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) with clinical outcome ranging from asymptomatic to severe disease, and even death to some. It posed a terrifying challenge to healthcare system worldwide. Several observational and clinical trials has reported that, Vitamin D deficiency has contributed to acute respiratory distress syndrome. Case fatality rate increases with age and comorbidities, both of which are associated with decreased Vitamin D level. Therefore, this study is done to study the prevalence of 25(OH)Vitamin D in RT-PCR positive COVID-19 cases and RT-PCR negative controls.This is a hospital based cross-sectional study conducted at Jawaharlal Nehru Institute of Medical Sciences, Manipur on 88 RT-PCR positive Covid-19 cases and 88 COVID-19 negative controls over a period of 2 years. Analysis of the sample was done by Liaison 25(OH) Vitamin D Total Chemiluminescence assay(CLIA).In this study, statistically significant (p-0.018) lower plasma 25(OH)Vitamin D level is seen in COVID-19 positive cases (median 28±20.47) when compared to Covid-19 negative controls(median 33.50±10.66). The number of 25(OH) Vitamin D deficient is higher in Covid-19 positive cases when compared to Covid-19 negative controls -46(52.3%) and 30(34%) respectively with a high statistically significant value (p-0.015).COVID-19 positive cases have higher tendency to have suboptimal plasma 25(OH) Vitamin D level which may contribute to the high hospitalization risk in COVID-19 infection. This finding is important as it can identify population at risk, and contribute to interventions in reducing the risk of hospitalization associated with COVID-19 infection.
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