早期不可预测的生活压力后慢性内脏疼痛的表观遗传调控的性别差异

Neurogastroenterology & Motility Pub Date : 2020-03-01 DOI:10.1111/nmo.13751

T. Louwies, B. Greenwood-Van Meerveld

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引用次数: 14

摘要

我们之前报道过，早期生活应激(ELS)会失调杏仁核中央核(CeA)中糖皮质激素受体(GR)和促肾上腺皮质激素释放激素(CRH)的表达。表观遗传修饰作为早期生活中发生的不良事件的记忆。因此，我们假设表观遗传机制改变了CeA中GR和CRH的表达，并成为ELS后慢性内脏疼痛的基础。

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Sex differences in the epigenetic regulation of chronic visceral pain following unpredictable early life stress

We previously reported that early life stress (ELS) dysregulated glucocorticoid receptor (GR) and corticotrophin‐releasing hormone (CRH) expression in the central nucleus of the amygdala (CeA). Epigenetic modifications serve as memories of adverse events that occurred during early life. Therefore, we hypothesized that epigenetic mechanisms alter GR and CRH expression in the CeA and underlie chronic visceral pain after ELS.

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Neurogastroenterology & Motility

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