数学建模工具在优化氢柠檬酸低聚亚甲基胍提纯工艺中的应用

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-12 DOI:10.3311/ppch.21380

D. Shatalov, K. Trachuk, A. Aydakova, Diana Akhmedova, I. Ivanov, D. Minenkov, I. Blazhevich, Daria Kirillova, S. Kedik

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引用次数: 0

摘要

目前的研究是致力于使用数学模型，特别是多因素分析方法的多标准优化(MAMO)在药物开发。在研究过程中，给出了算法序列，并进行了必要的测试。获得的数据通过MAMO进行解释。利用MAMO解决制备药物的原料药低聚亚甲基氢柠檬酸胍(OHMG-HC)纯化的应用问题的可能性。影响最终杂质含量的净化条件的依赖性以及使用建议算法作为药物开发手段的合理性。

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The Application of Mathematical Modeling Tools in Optimizing the Purification Process of the Substance Oligohexamethyleneguanidine Hydrocitrate

The current investigation is dedicated to the use of mathematical modeling, particularly the method of multifactorial analysis of multi-criteria optimization (MAMO) in pharmaceutical development. During the investigation the algorithmic sequence was offered and the necessary tests were provided. The gained data was interpreted through MAMO. The possibility of using the MAMO for solving the applied problem of purifying the oligohexamethyleneguanidine hydrocitrate (OHMG-HC) that is considered to be as a pharmaceutical substance for formation of medicines. The dependencies of purifying conditions that have influence on the final impurities contents and the reasonability of using the suggested algorithm as a means of pharmaceutical development.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.