非人类灵长类动物是多发性硬化症转化研究的重要模型

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2017-03-01 DOI:10.1016/j.ddmod.2018.01.001

Bert A. ‘t Hart , Che Serguera , Yolanda S. Kap , Bruno Gran

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引用次数: 0

摘要

老龄化的西方社会正面临着慢性炎症和退行性疾病日益普遍的问题，而目前尚无有效的治疗方法。药物开发行业面临着开发此类治疗方法的压力，因此需要与翻译相关的动物模型，这些模型可以忠实地复制人类疾病的基本致病机制。在这篇简短的综述中，我们讨论了非人灵长类动物(NHP)在自身免疫性神经系统疾病多发性硬化症(MS)发病机制和治疗的转化研究中的重要作用。

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Non-human primates are essential models in the translational research of multiple sclerosis

Ageing Western societies are facing an increasing prevalence of chronic inflammatory and degenerative diseases for which no effective treatments exist. The pressure on the drug development industry to develop such treatments creates a need for translationally relevant animal models, which faithfully replicate essential pathogenic mechanisms of the human disease. In this Short Review, we discuss the essential role of the non-human primate (NHP) in the translational research into the pathogenesis and treatment of the autoimmune neurological disease multiple sclerosis (MS).

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.