J. Vesper, A. Schnitzler, L. Wojtecki, P. Kleger, B. Landwehrmeyer
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引用次数: 0
摘要
脑深部刺激被批准用于治疗几种神经退行性疾病，但不适用于亨廷顿氏病。由于pallidal deep brain stimulation (DBS)对帕金森病患者左旋多巴诱导的神经张力障碍运动和神经张力障碍症状的显著影响，GPi的DBS最近已被应用于少数HD病例。这些标签外病例研究报告了医学上难治性舞蹈病的显著改善。我们之前对6名HD患者进行的随机前瞻性试验证实了苍白球刺激对舞蹈症张力障碍症状的有益作用，并建议苍白球的最佳靶点是GPi/GPe边界区，而不是单独针对GPi。
J08 Deep brain stimulation (DBS) of the globus pallidus (GP) in huntington’s disease (HD): a prospective, randomised, controlled, international, multi-centre study (HD-DBS)
Deep brain stimulation is an approved treatment for several neurodegenerative disorders but not for Huntington’s Disease. Because of the striking effects of pallidal deep brain stimulation (DBS) on choreodystonic movements induced by L-dopa in Parkinson’s disease and on dystonic symptoms, DBS of the GPi has recently been applied to a few single cases of HD. These off-label case studies report significant improvements of medically intractable chorea. Our previous randomised prospective pilot trial on 6 HD patients confirms the beneficial effects of pallidal stimulation on choreodystonic symptoms and suggests the optimal target site in the Globus pallidus to be at the GPi/GPe border zone rather than targeting the GPi alone.
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