响应面法优化羟丙基- β -环糊精制备工艺

2010 International Conference on Challenges in Environmental Science and Computer Engineering Pub Date : 2010-03-06 DOI:10.1109/CESCE.2010.139

Chao Yuan, Benguo Liu, Chungang Chen

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引用次数: 3

摘要

本研究对羟丙基-β-环糊精的制备工艺进行了优化，达到取代度和回收率。采用反应时间、反应温度、透析时间等因素组成的响应面中心复合设计，并采用反应率的二阶模型生成响应面。确定了最佳制备工艺条件:反应时间16.05 h，反应温度31.06℃，透析时间7.41 h。在最佳条件下得到的取代度和回收率分别为4.10%和60.23%。

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Optimization of Preparation Process of Hydroxypropyl-beta-Cyclodextrin by Response Surface Methodology

The preparation process of hydroxypropyl-β-cyclodextrin was optimized to the degree of substitution and recovery in this study. A central composite design of response surface methodology involving reaction time, reaction temperature, dialysis time was used, and second-order model for the yeild was employed to generate the response surface. The optimum condition for the preparation process was determined as follows: reaction time 16.05 h, reaction temperature 31.06 °C, dialysis time 7.41 h. The obtained degree of substitution and recovery at the optimum condition were 4.10 and 60.23%.

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2010 International Conference on Challenges in Environmental Science and Computer Engineering

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