A. Giordano, M. Luciani, F. Gatto, Monah Abou Alezz, Chiara Beghè, Lucrezia Della Volpe, A. Migliara, Sara Valsoni, M. Genua, M. Dzieciatkowska, Giacomo Frati, Julie Tahraoui-Bories, S. Giliani, S. Orcesi, E. Fazzi, Renato Ostuni, Angelo D’Alessandro, Raffaella Di Micco, I. Merelli, A. Lombardo, Martin A. M. Reijns, N. Gromak, A. Gritti, A. Kajaste-Rudnitski
{"title":"DNA损伤有助于aicardii - gouti<e:1>综合征星形胶质细胞的神经毒性炎症","authors":"A. Giordano, M. Luciani, F. Gatto, Monah Abou Alezz, Chiara Beghè, Lucrezia Della Volpe, A. Migliara, Sara Valsoni, M. Genua, M. Dzieciatkowska, Giacomo Frati, Julie Tahraoui-Bories, S. Giliani, S. Orcesi, E. Fazzi, Renato Ostuni, Angelo D’Alessandro, Raffaella Di Micco, I. Merelli, A. Lombardo, Martin A. M. Reijns, N. Gromak, A. Gritti, A. Kajaste-Rudnitski","doi":"10.1084/jem.20211121","DOIUrl":null,"url":null,"abstract":"Giordano et al. establish human AGS iPSC-based models of TREX1 or RNASEH2B deficiencies. They uncover DNA damage as a major driver of neurotoxic inflammation in AGS astrocytes that can be uncoupled from aberrant type I IFN responses and identify novel targets to curtail AGS neuroinflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"209 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"25","resultStr":"{\"title\":\"DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes\",\"authors\":\"A. Giordano, M. Luciani, F. Gatto, Monah Abou Alezz, Chiara Beghè, Lucrezia Della Volpe, A. Migliara, Sara Valsoni, M. Genua, M. Dzieciatkowska, Giacomo Frati, Julie Tahraoui-Bories, S. Giliani, S. Orcesi, E. Fazzi, Renato Ostuni, Angelo D’Alessandro, Raffaella Di Micco, I. Merelli, A. Lombardo, Martin A. M. Reijns, N. Gromak, A. Gritti, A. Kajaste-Rudnitski\",\"doi\":\"10.1084/jem.20211121\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Giordano et al. establish human AGS iPSC-based models of TREX1 or RNASEH2B deficiencies. They uncover DNA damage as a major driver of neurotoxic inflammation in AGS astrocytes that can be uncoupled from aberrant type I IFN responses and identify novel targets to curtail AGS neuroinflammation.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":\"209 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"25\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20211121\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20211121","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes
Giordano et al. establish human AGS iPSC-based models of TREX1 or RNASEH2B deficiencies. They uncover DNA damage as a major driver of neurotoxic inflammation in AGS astrocytes that can be uncoupled from aberrant type I IFN responses and identify novel targets to curtail AGS neuroinflammation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
