Fetuin A Levels Among Different Grades Of Obesity With Its Potential Link To Its Complication With Elaboration Of Physical Training Effects In Rats

We aimed to examine the link between fetuin A and different grades of obesity with its potential link to its complication and to determine the effect of exercise on its levels as well as on obesity complications. Methods: 40 male rats were classified based on adiposity index by using cluster analysis to 4 groups: G1: normal weight with no physical training n=10, G2: Overweight n=9, G3: Obese n=11 and G4: normal weight with physical training n=10. Albumin and creatinine were determined in urine and serum levels of fetuin-A, adiponectin, TNF-α, MDA, GSH, lipid profile and HOMA IR were measured. Also, liver NFkappa and renal relative AMPK mRNA expression were determined. Results: Fetuin–A, MDA, TNF-α, LDL, TG, HOMA IR, NFkappa, Adiposity index and ACR were significantly higher while adiponectin, GSH, HDL and relative AMPK mRNA expression were significantly lower in group2,3 as compared to group1,4 and as compared to each other. While, group3 showed significant increase in ACR, as compared to group1,2,4 but there was no significant change in ACR in group2. Group4 showed significant increase in adiponectin, GSH, HDL and relative AMPK mRNA expression and significant decrease in fetuin-A, TNF-α, MDA, HOMA IR, LDL ,TG, NFkappa, adiposity index and ACR as compared to group2,3. Also, positive correlation between fetuin-A and Adiposity index, ACR and NFkappa with negative correlation between it and adiponectin detected in group2,3,4.Conclusion: Fetuin-A level is directly proportional to obesity grades and its complication. Also, exercise appears to have protective role by decreasing fetuin-A level.