Study of the Role of Body Mass Index and Serum Leptin as Potential Risk Factors in Patients with Lifelong Premature Ejaculation

Introduction: several studies demonstrated the potential role of serum leptin in patients with premature ejaculation. Aim: we aimed in this study to evaluate the correlation between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation and healthy controls. Patients and Methods: this study was carried out on 80 consecutive patients and controls. Body mass index was measured in the patients and the controls. Serum leptin was measured in both groups at the end of the study. Additionally, the patients and the controls were asked to measure intra vaginal ejaculation latency time (IELT) by stop watch handled by their wives for 2 successive months. Results: our prospective analysis revealed a highly significant association between body mass index and serum leptin and intra-vaginal ejaculation latency time among the cases (p-value < 0.001, <0.001 respectively). Additionally, body mass index (BMI) did reveal significant association with intra-vaginal ejaculation latency time (p-value=0.014) only, without any association with serum leptin (p-value = 0.391) among the controls. Discussion: the current study demonstrated a statistically significant association between BMI and serum leptin and IELT in the patients with lifelong premature ejaculation. Additionally, the results revealed a statistically significant association between BMI and IELT in the controls without any association with the serum leptin. Conclusion: the current study highlights the role of both body mass index and serum leptin as potential risk factors in patients with lifelong premature ejaculation. Eventually, future studies are required to duplicate this interesting association between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation.