生发中心B细胞中的tgf - β信号传导促进了从亮区到暗区的转变

The Tokushima journal of experimental medicine Pub Date : 2019-09-10 DOI:10.1084/jem.20181868

Anne R Albright, J. Kabat, Moyi Li, Fiona Raso, A. Reboldi, J. Muppidi

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引用次数: 18

摘要

GCs被极化为LZ和DZ，以允许选择和增殖的空间分离。在这项研究中，我们描述了TGFβ在促进gcb从LZ向DZ转变中的先前未知的功能。

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TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone

GCs are polarized into LZ and DZ to allow for the spatial separation of selection and proliferation. In this study, we describe the previously unknown function of TGFβ in promoting the transition of GCBs from LZ to DZ.

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The Tokushima journal of experimental medicine

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