烯酮[2+2]环加成和环重排复分解合成螺环环丁烷衍生物

IF 0.5 4区化学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2020-12-16 DOI:10.56042/ijcb.v59i12.41816

S. Kotha, Sunil Pulletikurti

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引用次数: 0

摘要

本文以市售降冰片二烯和双环戊二烯为原料，以烯酮加成和环重排复合反应为关键步骤，简明地合成了螺环环丁烷四环和五环衍生物。该四环螺衍生物含有一个[5/5/4]核心单元，是合成角三醌的关键单元。然而，五环螺衍生物包含一个基本的核心骨架的预苯四烯，和其他倍半萜类。

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Synthesis of spiro-annulated cyclobutane derivatives through ketene [2+2] cycloaddition and ring-rearrangement metathesis

Herein is reported a concise synthesis of spiro-annulated cyclobutane tetracyclic and pentacyclic derivatives by ketene addition, and ring-rearrangement metathesis (RRM) as key steps, starting with commercially available norbornadiene and dicyclopentadiene. The tetracyclic spiro-derivative contains a [5/5/4] core unit, which is the key building block to angular triquinanes synthesis. Whereas, the pentacyclic spiro-derivative contains a basic core skeleton of presilphiperfolanes, and other sesquiterpenoids.

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来源期刊

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry 化学-有机化学

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".