OP03.18: Brain echogenicities in fetuses at risk for preterm birth

syndrome). After birth three children showed neurological handicaps in two cases due to postnatally detected syndromes: one Sotos syndrome and one Goldenhar syndrome and one case related to progression of the ventriculomegaly. Conclusions: The outcome of fetuses with isolated mild ventriculomegaly is mostly favorable. Chromosomal anomalies should be excluded in all cases with MVM since in 4.1% of the fetuses trisomy 21 was proven. The risk for a chromosomal anomaly is higher when additional soft markers for aneuploidy are present. Previously published studies on this topic did not take the role of soft markers into consideration. In cases with MVM accompanied by normal karyotype the risk for prenatal and postnatal mortality and morbidity is increased as compared to sonographically normal fetuses.