A. Foroumadi, S. Tabatabai, G. Gitinezhad, M. Zarrindast, A. Shafiee
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引用次数: 13
摘要
合成了5-芳基-1,3,4-噻二唑衍生物，并采用戊四唑致死性惊厥试验检测了其抗惊厥活性。结果表明，2-氨基衍生物具有抗兀蚁活性(LD50 > 500mg kg - 1)，且这种作用不通过苯二氮卓类受体介导。苯基环上的氟吸电子取代基没有增强化合物的活性。
SYNTHESIS AND ANTICONVULSANT ACTIVITY OF 5-ARYL-1,3,4-THIADIAZOLE DERIVATIVES
5-Aryl-1,3,4-thiadiazole derivatives were synthesized and tested for anticonvulsant activity using the pentylenetetrazole-induced lethal convulsion test. The results showed that 2-amino derivatives have anticon vulsant activity (LD50 > 500mg kg−1) and this effect was not mediated through benzodiazepine receptors. The fluoro electron-withdrawing substituent on the phenyl ring did not potentiate the activity of the compounds.
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