{"title":"饮用咖啡对内分泌的影响","authors":"Ceyda Dinçer, T. Apaydın, D. Yavuz","doi":"10.25179/tjem.2019-71878","DOIUrl":null,"url":null,"abstract":"Introduction Coffee is one of the most popular beverages consumed worldwide, thereby enhancing its market demand (1). Statistics reveal that the average consumption of coffee ranges from 2-4 cups per day in western societies. Western countries prefer to consume brewed coffee while instant coffee is popular among the North Europeans. Boiled coffee is frequently consumed by the inhabitants of the Balkan area, Ireland, North Africa, and Turkey. Scientists have extracted numerous bioactive compounds, such as chlorogenic acids (CGA), polyphenols, diterpenes, caffeine, and caffeine metabolites (1,2) from this complex beverage. Abstract Caffeine has been found to exert various biological effects including, antiangiogenic, antiproliferative, antimetastatic activity, increased fat oxidation and mobilization of glycogen in muscle, increased lipolysis, and reduction of body fat. The aim of this review is to analyze the endocrine effects of coffee consumption. A systematic literature search was conducted on PubMed and Web of Science databases seeking articles published until May 2019, dealing with coffee consumption and diabetes, osteoporosis, thyroid gland, adrenal, and gonads. The results of the most epidemiologic studies reported that coffee consumption has positive effects on combating type 2 diabetes risk, has no significant effects on bone mineral density levels but fracture risk was shown to be higher in the high coffee consumer group. Coffee intake has no significant effect on thyroid cancer, increases sex hormone binding globulin levels, has no effect on fertility but higher consumption was related to spontaneous abortion. Studies pertaining to coffee consumption and endocrine effects have contrary results. More randomized clinical studies with a long term follow up period are required.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"74 3 1","pages":"72-86"},"PeriodicalIF":0.2000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Endocrine Effects of Coffee Consumption\",\"authors\":\"Ceyda Dinçer, T. Apaydın, D. Yavuz\",\"doi\":\"10.25179/tjem.2019-71878\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction Coffee is one of the most popular beverages consumed worldwide, thereby enhancing its market demand (1). Statistics reveal that the average consumption of coffee ranges from 2-4 cups per day in western societies. Western countries prefer to consume brewed coffee while instant coffee is popular among the North Europeans. Boiled coffee is frequently consumed by the inhabitants of the Balkan area, Ireland, North Africa, and Turkey. Scientists have extracted numerous bioactive compounds, such as chlorogenic acids (CGA), polyphenols, diterpenes, caffeine, and caffeine metabolites (1,2) from this complex beverage. Abstract Caffeine has been found to exert various biological effects including, antiangiogenic, antiproliferative, antimetastatic activity, increased fat oxidation and mobilization of glycogen in muscle, increased lipolysis, and reduction of body fat. The aim of this review is to analyze the endocrine effects of coffee consumption. A systematic literature search was conducted on PubMed and Web of Science databases seeking articles published until May 2019, dealing with coffee consumption and diabetes, osteoporosis, thyroid gland, adrenal, and gonads. The results of the most epidemiologic studies reported that coffee consumption has positive effects on combating type 2 diabetes risk, has no significant effects on bone mineral density levels but fracture risk was shown to be higher in the high coffee consumer group. Coffee intake has no significant effect on thyroid cancer, increases sex hormone binding globulin levels, has no effect on fertility but higher consumption was related to spontaneous abortion. Studies pertaining to coffee consumption and endocrine effects have contrary results. More randomized clinical studies with a long term follow up period are required.\",\"PeriodicalId\":42868,\"journal\":{\"name\":\"Turkish Journal of Endocrinology and Metabolism\",\"volume\":\"74 3 1\",\"pages\":\"72-86\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Turkish Journal of Endocrinology and Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.25179/tjem.2019-71878\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Journal of Endocrinology and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25179/tjem.2019-71878","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 2
摘要
咖啡是世界上最受欢迎的饮料之一,因此增加了它的市场需求(1)。统计数据显示,在西方社会,咖啡的平均消费量在每天2-4杯之间。西方国家更喜欢喝煮好的咖啡,而速溶咖啡在北欧人中很受欢迎。巴尔干地区、爱尔兰、北非和土耳其的居民经常饮用煮咖啡。科学家们已经从这种复杂的饮料中提取了许多生物活性化合物,如绿原酸(CGA)、多酚、二萜、咖啡因和咖啡因代谢物(1,2)。咖啡因具有多种生物效应,包括抗血管生成、抗增殖、抗转移活性、增加脂肪氧化和肌肉中糖原的动员、增加脂肪分解和减少体脂。这篇综述的目的是分析咖啡消费对内分泌的影响。在PubMed和Web of Science数据库上进行了系统的文献检索,寻找截至2019年5月发表的关于咖啡消费与糖尿病、骨质疏松症、甲状腺、肾上腺和性腺的文章。大多数流行病学研究的结果表明,喝咖啡对对抗2型糖尿病风险有积极作用,对骨密度水平没有显著影响,但高咖啡消费群体的骨折风险更高。咖啡摄入对甲状腺癌没有显著影响,增加性激素结合球蛋白水平,对生育能力没有影响,但高摄入量与自然流产有关。有关咖啡消费和内分泌影响的研究得出了相反的结果。需要更多的随机临床研究和长期随访。
Introduction Coffee is one of the most popular beverages consumed worldwide, thereby enhancing its market demand (1). Statistics reveal that the average consumption of coffee ranges from 2-4 cups per day in western societies. Western countries prefer to consume brewed coffee while instant coffee is popular among the North Europeans. Boiled coffee is frequently consumed by the inhabitants of the Balkan area, Ireland, North Africa, and Turkey. Scientists have extracted numerous bioactive compounds, such as chlorogenic acids (CGA), polyphenols, diterpenes, caffeine, and caffeine metabolites (1,2) from this complex beverage. Abstract Caffeine has been found to exert various biological effects including, antiangiogenic, antiproliferative, antimetastatic activity, increased fat oxidation and mobilization of glycogen in muscle, increased lipolysis, and reduction of body fat. The aim of this review is to analyze the endocrine effects of coffee consumption. A systematic literature search was conducted on PubMed and Web of Science databases seeking articles published until May 2019, dealing with coffee consumption and diabetes, osteoporosis, thyroid gland, adrenal, and gonads. The results of the most epidemiologic studies reported that coffee consumption has positive effects on combating type 2 diabetes risk, has no significant effects on bone mineral density levels but fracture risk was shown to be higher in the high coffee consumer group. Coffee intake has no significant effect on thyroid cancer, increases sex hormone binding globulin levels, has no effect on fertility but higher consumption was related to spontaneous abortion. Studies pertaining to coffee consumption and endocrine effects have contrary results. More randomized clinical studies with a long term follow up period are required.