Equilin。

IF 0.8 4区化学

Acta crystallographica. Section C, Crystal structure communications Pub Date : 2020-02-07 DOI:10.32388/p7gw5m

M. Sawicki, N. Li, D. Ghosh

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引用次数: 0

摘要

3-羟基-1,3,5(10)，7-tetraen-17-one, C18H20O2，由乙酸乙酯在P2(1)2(1)2(1)空间群中结晶。B环的平面性，以及C环和D环与雌酮不同的褶皱性，是由于C7 = C8双键的存在，这可能解释了它作为人1 17型β -羟基类固醇脱氢酶抑制剂的功能，而不是它的底物。

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Equilin.

3-Hydroxyestra-1,3,5(10),7-tetraen-17-one, C18H20O2, crystallizes in space group P2(1)2(1)2(1) from ethyl acetate. The planarity of the B ring, and the difference in puckering of the C and D rings from that of estrone, are due to the presence of the C7 = C8 double bond, which may explain its function as an inhibitor of human type 1 17 beta-hydroxysteroid dehydrogenase, instead of being its substrate.

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来源期刊

Acta crystallographica. Section C, Crystal structure communications 化学-晶体学

自引率

12.50%

发文量

审稿时长

1 months

期刊介绍： Acta Crystallographica Section C: Structural Chemistry is continuing its transition to a journal that publishes exciting science with structural content, in particular, important results relating to the chemical sciences. Section C is the journal of choice for the rapid publication of articles that highlight interesting research facilitated by the determination, calculation or analysis of structures of any type, other than macromolecular structures. Articles that emphasize the science and the outcomes that were enabled by the study are particularly welcomed. Authors are encouraged to include mainstream science in their papers, thereby producing manuscripts that are substantial scientific well-rounded contributions that appeal to a broad community of readers and increase the profile of the authors.