与蛋白尿和尿酸相比,尿钙/肌酐比值在预测子痫前期的作用:一项来自科索沃的研究

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Lindita Ibrahimi, M. Paçarada, Syheda Latifi Hoxha, A. Bimbashi, Vlora Ademi Ibishi
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引用次数: 2

摘要

背景子痫前期是一种常见的妊娠并发症,也是全世界母婴发病率和死亡率的主要原因。本研究旨在探讨尿钙/肌酐比值与蛋白尿和尿酸在预测子痫前期的作用。材料/方法本前瞻性病例对照研究将200例参与研究的孕妇连续分为3组:子痫前期孕妇组59例,妊高征孕妇组61例,血压正常孕妇组80例。在孕24-34周时收集24小时尿液样本用于估计钙/肌酐比率和蛋白尿,并收集血液样本用于估计尿酸。结果蛋白尿作为子痫前期预测指标的敏感性为96.6% (P=0.000),特异性为21.3%。尿酸作为预测指标的敏感性为96.6% (P=0.000),特异性为48.8%;而对于24小时尿钙/肌酐比值,敏感性为87.9% (P=0.000),特异性为40.7%,对应值为0.105(截止值)。钙/肌酐比值<0.105的妇女发生子痫前期的风险较高(置信区间为87.9%,P=0.000)。结论尿钙/肌酐比值在预测子痫前期的作用不如蛋白尿和尿酸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Calcium/Creatinine Ratio in Urine Compared with Proteinuria and Uric Acid in Predicting Preeclampsia: A Study from Kosovo
Background Preeclampsia is a common complication of pregnancy and a major cause of morbidity and mortality of mothers and babies worldwide. This study aimed to explore what the role of calcium/creatinine ratio is in urine compared with proteinuria and uric acid in predicting preeclampsia. Material/Methods In this prospective case-control study, 200 pregnant women who participated in the study were consecutively divided into 3 groups: a group of 59 women with preeclampsia, 61 women with pregnancy-induced hypertension, and a control group of 80 normotensive pregnant women. A 24-h urine sample was collected for estimation of calcium/creatinine ratio and proteinuria and a blood sample for estimation of uric acid at a gestational age of 24–34 weeks of pregnancy. Results The study found that the sensitivity of proteinuria as a predictor of preeclampsia was 96.6% (P=0.000) and specificity was 21.3%. The sensitivity of uric acid as a predictor was 96.6% (P=0.000) and the specificity was 48.8%; whereas for the 24-h urine calcium/creatinine ratio, the sensitivity was 87.9% (P=0.000) and the specificity 40.7%, which corresponds to a value of 0.105 (cutoff). Women with a calcium/creatinine ratio <0.105 have a higher risk of developing preeclampsia (87.9% confidence interval, P=0.000). Conclusions The role of the calcium/creatinine ratio in urine is inferior to proteinuria and uric acid in predicting preeclampsia.
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来源期刊
Medical Science Monitor Basic Research
Medical Science Monitor Basic Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
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